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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jul 15, 2019; 11(7): 538-550
Published online Jul 15, 2019. doi: 10.4251/wjgo.v11.i7.538
Published online Jul 15, 2019. doi: 10.4251/wjgo.v11.i7.538
Intraoperative intraperitoneal chemotherapy increases the incidence of anastomotic leakage after anterior resection of rectal tumors
Zhi-Jie Wang, Jin-Hua Tao, Jia-Nan Chen, Shi-Wen Mei, Hai-Yu Shen, Fu-Qiang Zhao, Qian Liu, Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union College, Beijing 100021, China
Author contributions: Wang ZJ and Tao JH designed the research; Chen JN, Mei SW, Shen HY, and Zhao FQ collected and analyzed the data; Wang ZJ drafted the article; Liu Q revised the paper.
Supported by Medicine and Health Technology Innovation Project of Chinese Academy of Medical Sciences , No. 2017-12M-1-006 .
Institutional review board statement: Our investigation received approval from the ethics committee of the National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union College.
Informed consent statement: All patients have signed an informed consent form before the study.
Conflict-of-interest statement: The authors declare that there is no conflict of interest in regard to this research.
STROBE statement: The authors have carefully read the STROBE Statement checklist of items and prepared the manuscript based on the requirements of STROBE Statement checklist of items.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Qian Liu, MD, Professor, Department of Colorectal Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union College, No. 17, Panjiayuan Nanli, Chaoyang District, Beijing 100021, China. fcwpumch@163.com
Telephone: +86-10-87787110 Fax: +86-10-87787110
Received: January 27, 2019
Peer-review started: January 28, 2019
First decision: April 15, 2019
Revised: May 1, 2019
Accepted: May 28, 2019
Article in press: May 29, 2019
Published online: July 15, 2019
Peer-review started: January 28, 2019
First decision: April 15, 2019
Revised: May 1, 2019
Accepted: May 28, 2019
Article in press: May 29, 2019
Published online: July 15, 2019
Core Tip
Core tip: Intraoperative intraperitoneal chemotherapy is gradually administered during operations for locally advanced rectal cancer patients. It is believed that this treatment can improve the oncological outcomes and survival rates. However, surgical complications related to intraoperative chemotherapy have also been reported. We conducted this study to determine the relationship between intraperitoneal chemotherapy and anastomotic leakage to help surgeons weigh the benefits and risks of intraoperative chemotherapy.