Published online Jun 15, 2018. doi: 10.4251/wjgo.v10.i6.124
Peer-review started: February 23, 2018
First decision: March 23, 2018
Revised: March 23, 2018
Accepted: April 19, 2018
Article in press: April 19, 2018
Published online: June 15, 2018
Core tip: Gastric cancer (GC) has high cancer-related mortality, which is mainly caused by distant metastasis including hematogenous metastasis. Numerous steps are required to establish a metastatic focus, and understanding the molecular mechanisms of each step is necessary to conquer metastasis. Development and dissemination of sequencing technology have elucidated some of the molecular biological mechanisms associated with cancer metastasis. This review aims to summarize the molecules reportedly contributing to hematogenous metastasis from GC and to become the groundwork for the further development of novel biomarkers and molecular targets.