Suguru Maruyama, Shinji Furuya, Kensuke Shiraishi, Hiroki Shimizu, Hidenori Akaike, Naohiro Hosomura, Yoshihiko Kawaguchi, Hidetake Amemiya, Hiromichi Kawaida, Makoto Sudo, Shingo Inoue, Hiroshi Kono, Daisuke Ichikawa, First Department of Surgery, Faculty of Medicine University of Yamanashi, Yamanashi 409-3898, Japan
Author contributions: Maruyama S performed the majority of experiments and wrote the manuscript; Furuya S performed the research; Shiraishi K, Akaike H and Kawaguchi Y provided tissue samples and clinical data; Shimizu H, Hosomura N, Amemiya H, Kawaida H, Sudo M, Inoue S and Kono H made substantial contributions to the data analysis and interpretation; Ichikawa D designed the research and helped to draft the manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Yamanashi University (approved number: 1825) and was performed in accordance with the ethical standards of the Declaration of Helsinki and its later amendments.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Daisuke Ichikawa, MD, PhD, Professor, First Department of Surgery, Faculty of Medicine University of Yamanashi, 1110 Shimokato, Chuou, Yamanashi 409-3898, Japan. firstname.lastname@example.org
Telephone: +81-55-2737390 Fax: +81-55-2737390
Received: July 4, 2018
Peer-review started: July 5, 2018
First decision: July 24, 2018
Revised: August 5, 2018
Accepted: August 30, 2018
Article in press: August 31, 2018
Published online: October 15, 2018