Morales-Maza J, Pastor-Sifuentes FU, Sánchez-Morales GE, Ramos ESG, Santes O, Clemente-Gutiérrez U, Pimienta-Ibarra AS, Medina-Franco H. Clinical characteristics and surgical treatment of schwannomas of the esophagus and stomach: A case series and systematic review. World J Gastrointest Oncol 2019; 11(9): 750-760 [PMID: 31558979 DOI: 10.4251/wjgo.v11.i9.750]
Corresponding Author of This Article
Heriberto Medina-Franco, FACS, MD, Associate Professor, Department of Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán,Vasco de Quiroga 15, Sección XVI, Tlalpan, Mexico City14080, Mexico.herimd@hotmail.com
Research Domain of This Article
Surgery
Article-Type of This Article
Systematic Reviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Sep 15, 2019; 11(9): 750-760 Published online Sep 15, 2019. doi: 10.4251/wjgo.v11.i9.750
Clinical characteristics and surgical treatment of schwannomas of the esophagus and stomach: A case series and systematic review
Jesús Morales-Maza, Francisco Ulises Pastor-Sifuentes, Germán E Sánchez-Morales, Emilio Sanchez-Garcia Ramos, Oscar Santes, Uriel Clemente-Gutiérrez, Adriana Simoneta Pimienta-Ibarra, Heriberto Medina-Franco
Jesús Morales-Maza, Francisco Ulises Pastor-Sifuentes, Germán E Sánchez-Morales, Emilio Sanchez-Garcia Ramos, Oscar Santes, Uriel Clemente-Gutiérrez, Adriana Simoneta Pimienta-Ibarra, Heriberto Medina-Franco, Department of Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City14080, Mexico
Author contributions: Morales-Maza J, Pastor-Sifuentes FU, Sánchez-Morales GE and Medina-Franco H contributed equally to this study; Santes O and Clemente-Gutiérrez U performed the research and analyzed the data; Pimienta-Ibarra AS and Sanchez-Garcia Ramos E. wrote the paper.
Conflict-of-interest statement: No potential conflicts of interest. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Heriberto Medina-Franco, FACS, MD, Associate Professor, Department of Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán,Vasco de Quiroga 15, Sección XVI, Tlalpan, Mexico City14080, Mexico.herimd@hotmail.com
Telephone: +1-52-54870900 Fax: +1-52-54870900
Received: February 12, 2019 Peer-review started: February 15, 2019 First decision: April 15, 2019 Revised: May 5, 2019 Accepted: August 18, 2019 Article in press: August 19, 2019 Published online: September 15, 2019
ARTICLE HIGHLIGHTS
Research background
Schwannomas are benign neoplasms originated from Schwann cells. Schwannomas are more commonly locate in the stomach. Schwannomas are usually asymptomatic lesions.
Research objectives
We have reviewed the available literature about gastrointestinal schwannomas, especially lesions from de stomach and esophagus (diagnosis, treatment, and follow up).
Research methods
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes guidelines, a systematic review was conducted. The PubMed, Ovid, MEDLINE, and Scopus databases were used for reviewing process. Only English language manuscripts were included. All gastrointestinal schwannomas specifically located in the esophagus and stomach were included, and cases that did not report long-term follow-up were excluded.
Research results
Gastric localization showed a higher prevalence in both, the literature review and our institution. With a follow-up with disease-free survival greater than 36 mo in most cases. In both groups, the median size was > 4.1 cm. Surgical treatment is curative in most cases.
Research conclusions
Schwannoma must be taken into account in the differential diagnosis of gastrointestinal mesenchymal tumors. Schwannoma has a good prognosis, and most are benign.A disease-free survival of more than 36 mo can be achieved by surgery.
