Published online Aug 15, 2019. doi: 10.4251/wjgo.v11.i8.634
Peer-review started: March 20, 2019
First decision: June 4, 2019
Revised: June 7, 2019
Accepted: June 20, 2019
Article in press: June 20, 2019
Published online: August 15, 2019
Localized oeso-gastric cancer (GC) are treated by perioperative chemotherapy and surgery. The use of taxane seems to improve response rate and outcome.
Only the efficacy of the german regimen FLOT was previously reports.
To determine the efficacy of the Frence TeFOX regimen.
This retrospective study aims to test efficacy and safety of the perioperative TeFOX regimen given alone in patients with localized GC.
Thirty-three consecutive patients were included. Median follow-up of surviving patients was 32 mo. R0 resection was obtained in 30 (91) patients. Twelve patients (36) have a pathological complete response and 8 (24) patients a nearly complete pathological response.
TeFOX regimen could be safely administrated in perioperative treatment of localized GC.
TeFOX and the FLOT regimen have comparable efficacy and safety profiles and could be considered as an alternative regimen.