Published online Jun 15, 2019. doi: 10.4251/wjgo.v11.i6.489
Peer-review started: March 8, 2019
First decision: May 13, 2019
Revised: May 15, 2019
Accepted: May 28, 2019
Article in press: May 29, 2019
Published online: June 15, 2019
Because of the occultation of hepatic hilar cholangiocarcinoma, most patients have lost the opportunity for surgical radical treatment at the time of diagnosis. Palliative treatment is important for patients with hepatic hilar cholangiocarcinoma.
Simple reduction of jaundice may fail due to tumor progression, and effective and combined palliative treatment may prolong the effective drainage time of the biliary stent or drainage tube, thereby prolonging patient survival. However, relevant research is rare at present.
This study mainly investigated the effects of transcatheter arterial chemoembolization (TACE) combined with radiotherapy on the survival of patients with hilar cholangiocarcinoma after biliary stent or drainage tube implantation, and analyzed the influencing factors.
This study used a retrospective cohort analysis to determine the significance of TACE combined with radiotherapy by comparing the differences between the two groups and comparing the different methods of reducing jaundice (stent or drainage tube placement) within the group. Regression analysis of the overall data helps to identify the independent factors influencing survival.
There was no significant difference in survival between the control group and the combination treatment group, which were treated by stent or tube implantation for the treatment of reducing jaundice, while the survival of patients receiving TACE combined with radiotherapy was significantly longer than that of patients receiving simple reduction of jaundice.
The results showed that TACE combined with radiotherapy can significantly extend the effective drainage time of stent or tube and prolong the survival of patients. Co-treatment, Bismuth-Corlett type IV, percutaneous biliary drainage, and age were independent predictors of survival.
Accepting a reasonable and standardized palliative treatment will prolong the survival of patients with unresectable hilar cholangiocarcinoma and improve their living conditions. With the development of immunotherapy and targeted therapy, relevant research may be carried out in the future.