Published online Jan 15, 2019. doi: 10.4251/wjgo.v11.i1.9
Peer-review started: October 18, 2018
First decision: November 14, 2018
Revised: December 5, 2018
Accepted: December 17, 2018
Article in press: December 17, 2018
Published online: January 15, 2019
The worldwide mortality rate of colorectal cancer (CRC) is about one half of its morbidity. Ubiquitin is a key regulatory factor in the cell cycle and widely exists in eukaryotes. Human leukocyte antigen F-associated transcript 10 (FAT10), also known as diubiquitin, is an 18-kDa protein with 29% and 36% homology with the N and C termini of ubiquitin, respectively.
The function of FAT10 has not been fully elucidated, and some studies have shown that it plays an important role in various cell processes.
The objective of this study is to examine FAT10 expression and to analyze the relationship between FAT10 expression and the clinicopathological parameters of CRC.
Immunohistochemistry and Western blotting were used to measure FAT10 expression in 61 cases of CRC and para-cancer colorectal tissues. In addition, the relationship between FAT10 expression and the clinicopathological parameters of CRC was statistically analyzed.
Immunohistochemical analysis showed that the positive rate of FAT10 expression in CRC was significantly higher than in tumor-adjacent tissue and normal colorectal mucosal tissue. Western blotting indicated that FAT10 expression was significantly higher in CRC than in tumor-adjacent tissue. FAT10 expression was closely associated with clinical stage and lymphatic spread of CRC.
FAT10 expression is highly upregulated in CRC and is closely associated with clinical stage and lymphatic spread of CRC.
Further exploration of the role of FAT10 in the development of CRC and the underlying mechanisms, especially its relationship with the cell cycle, will be important for understanding the value of FAT10 in CRC diagnosis, prognosis and therapy.