Published online Feb 15, 2017. doi: 10.4251/wjgo.v9.i2.70
Peer-review started: August 10, 2016
First decision: September 12, 2016
Revised: October 16, 2016
Accepted: November 21, 2016
Article in press: November 22, 2016
Published online: February 15, 2017
To investigate the outcomes of liver and pancreatic resections for renal cell carcinoma (RCC) metastatic disease.
This is a retrospective, single centre review of liver and/or pancreatic resections for RCC metastases between January 2003 and December 2015. Descriptive statistical analysis and survival analysis using the Kaplan-Meier estimation were performed.
Thirteen patients had 7 pancreatic and 7 liver resections, with median follow-up 33 mo (range: 3-98). Postoperative complications were recorded in 5 cases, with no postoperative mortality. Three patients after hepatic and 5 after pancreatic resection developed recurrent disease. Median overall survival was 94 mo (range: 23-94) after liver and 98 mo (range: 3-98) after pancreatic resection. Disease-free survival was 10 mo (range 3-55) after liver and 28 mo (range 3-53) after pancreatic resection.
Our study shows that despite the high incidence of recurrence, long term survival can be achieved with resection of hepatic and pancreatic RCC metastases in selected cases and should be considered as a management option in patients with oligometastatic disease.
Core tip: The evidence on the role of surgery in management of renal cell carcinoma (RCC) metastatic disease to the liver and pancreas remains limited due to the rare nature of the disease. We have treated 13 patients in our institution, achieving median overall survival of 94 mo (range: 23-94) after liver and 98 mo (range: 3-98) after pancreatic resection. Disease-free survival was 10 mo (range: 3-55) after liver and 28 mo (range: 3-53) after pancreatic resection. Long term survival can be achieved with resection of hepatic and pancreatic RCC metastases in selected cases and should be considered in patients with oligometastatic disease.