Published online Aug 15, 2015. doi: 10.4251/wjgo.v7.i8.123
Peer-review started: March 23, 2015
First decision: April 10, 2015
Revised: June 29, 2015
Accepted: July 11, 2015
Article in press: July 14, 2015
Published online: August 15, 2015
We reported 5 cases of granular cell tumors (GCTs) of esophagus and reviewed the literature. There were 4 females and 1 male with a median age of 43 years and an average age of 44 years. All of the cases had solitary tumors. Tumor size was 0.4-2.5 cm in diameter. Gastroscopy revealed that 2 cases were located in the middle esophagus, 1 case in the upper esophagus, and 2 cases in the distal one. Five cases displayed gray-white, pink, yellow mucosal uplifts of esophagus, 3 cases had smooth surface, 1 case was slightly concave, and the biggest tumor had erosion. Tumor cells were large and polygonal with rich granular and eosinophilic cytoplasm, and small oval nuclei. Cells were arranged in nest or aciniform. Immunohistochemistry and histochemistry staining showed S-100+, neuron specific enolase+, Vim+, CD68+, smooth muscle actin-, Des-, CK-, CD117-, CD34-, Ki67-or ≤ 5%+. Periodic acid-Schiff reaction and epithelial membrane antigen were both weakly positive. GCTs of esophagus are rare and most of the cases have good prognosis.
Core tip: Granular cell tumors (GCTs) of esophagus are rare and most of the cases have good prognosis. We reported 5 cases of GCTs of esophagus and reviewed the literature. The report is helpful in comprehensively understanding the characteristics of GCTs and guiding the treatment of this disease.