Case Report
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2015; 7(8): 123-127
Published online Aug 15, 2015. doi: 10.4251/wjgo.v7.i8.123
Esophageal granular cell tumors: Case report and literature review
Hong-Qun Wang, Ai-Jun Liu
Hong-Qun Wang, Department of Pathology, the Third People’s Hospital of Hefei, Hefei 230032, Anhui Province, China
Hong-Qun Wang, Ai-Jun Liu, Department of Pathology, the People’s Liberation Army General Hospital, Beijing 100853, China
Author contributions: Wang HQ collected the clinical data and wrote the manuscript; Liu AJ revised the manuscript.
Institutional review board statement: The study was approved by Research Ethics Committee of the Third People’s Hospital of Hefei and the Chinese Peoples Liberation Army General Hospital in China.
Informed consent statement: The study participant provided informed written consent prior to the study.
Conflict-of-interest statement: The authors declare that there are no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Ai-Jun Liu, Chief Physician and Associate Professor, Department of Pathology, the People’s Liberation Army General Hospital, 28# Fuxing Rd., Beijing 100853, China.
Telephone: +86-10-66936258 Fax: +86-10-66936258
Received: March 22, 2015
Peer-review started: March 23, 2015
First decision: April 10, 2015
Revised: June 29, 2015
Accepted: July 11, 2015
Article in press: July 14, 2015
Published online: August 15, 2015

We reported 5 cases of granular cell tumors (GCTs) of esophagus and reviewed the literature. There were 4 females and 1 male with a median age of 43 years and an average age of 44 years. All of the cases had solitary tumors. Tumor size was 0.4-2.5 cm in diameter. Gastroscopy revealed that 2 cases were located in the middle esophagus, 1 case in the upper esophagus, and 2 cases in the distal one. Five cases displayed gray-white, pink, yellow mucosal uplifts of esophagus, 3 cases had smooth surface, 1 case was slightly concave, and the biggest tumor had erosion. Tumor cells were large and polygonal with rich granular and eosinophilic cytoplasm, and small oval nuclei. Cells were arranged in nest or aciniform. Immunohistochemistry and histochemistry staining showed S-100+, neuron specific enolase+, Vim+, CD68+, smooth muscle actin-, Des-, CK-, CD117-, CD34-, Ki67-or ≤ 5%+. Periodic acid-Schiff reaction and epithelial membrane antigen were both weakly positive. GCTs of esophagus are rare and most of the cases have good prognosis.

Keywords: Immunohistochemistry, Granular cell tumors of esophagus, Gastroscope examination

Core tip: Granular cell tumors (GCTs) of esophagus are rare and most of the cases have good prognosis. We reported 5 cases of GCTs of esophagus and reviewed the literature. The report is helpful in comprehensively understanding the characteristics of GCTs and guiding the treatment of this disease.