Norton SE, Ward-Hartstonge KA, Taylor ES, Kemp RA. Immune cell interplay in colorectal cancer prognosis. World J Gastrointest Oncol 2015; 7(10): 221-232 [PMID: 26483876 DOI: 10.4251/wjgo.v7.i10.221]
Corresponding Author of This Article
Roslyn A Kemp, PhD, Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9010, New Zealand. roslyn.kemp@otago.ac.nz
Research Domain of This Article
Immunology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. Oct 15, 2015; 7(10): 221-232 Published online Oct 15, 2015. doi: 10.4251/wjgo.v7.i10.221
Immune cell interplay in colorectal cancer prognosis
Samuel E Norton, Kirsten A Ward-Hartstonge, Edward S Taylor, Roslyn A Kemp
Samuel E Norton, Kirsten A Ward-Hartstonge, Edward S Taylor, Roslyn A Kemp, Department of Microbiology and Immunology, University of Otago, Dunedin 9010, New Zealand
Author contributions: Norton SE and Ward-Hartstonge KA contributed equally to this work; all authors contributed to conceptualisation and wrote the paper.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article exist.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Roslyn A Kemp, PhD, Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9010, New Zealand. roslyn.kemp@otago.ac.nz
Telephone: +64-3-4797708 Fax: +64-3-4798540
Received: April 28, 2015 Peer-review started: May 7, 2015 First decision: June 2, 2015 Revised: June 12, 2015 Accepted: August 25, 2015 Article in press: August 28, 2015 Published online: October 15, 2015
Abstract
The immune response to colorectal cancer has proven to be a reliable measure of patient outcome in several studies. However, the complexity of the immune response in this disease is not well understood, particularly the interactions between tumour-associated cells and cells of the innate and adaptive immune system. This review will discuss the relationship between cancer associated fibroblasts and macrophages, as well as between macrophages and T cells, and demonstrate how each population may support or prevent tumour growth in a different immune environment.
Core tip: The outcome of patients with colorectal cancer is influenced by the complex local immune system. Understanding how multiple relationships between immune cells may affect tumour growth or elimination will be key in designing new therapies to treat this disease.
