Vitamin D and colon cancer

Abstract

Calcitriol, 1α, 25-dihydroxyvitamin D₃ (1,25 (OH)₂D₃), the most active form of vitamin D, is a pleotropic hormone with a wide range of biological activities. Due to its ability to regulate calcium and phosphate metabolism, 1,25D₃ plays a major role in bone health. In addition, 1,25D₃ binds to the vitamin D receptor and thereby regulates the expression of a number of genes which control growth, differentiation and survival of cancer cells. In agreement, the levels of vitamin D₃ appear to be an essential determinant for the development and progression of colon cancer and supplementation with vitamin D₃ is effective in suppressing intestinal tumorigenesis in animal models. Vitamin D₃ has been estimated to lower the incidence of colorectal cancer by 50%, which is consistent with the inverse correlation between dietary vitamin D₃ intake or sunlight exposure and human colorectal cancer. Several studies confirmed that increasing vitamin D₃ lowers colon cancer incidence, reduces polyp recurrence, and that sufficient levels of vitamin D₃ are associated with better overall survival of colon cancer patients. Vitamin D regulates the homeostasis of intestinal epithelium by modulating the oncogenic Wnt signaling pathway and by inhibiting tumor-promoting inflammation. Both activities contribute to the ability of 1,25D₃ to prevent the development and progression of colon cancer.

Keywords: Colon cancer, Vitamin D, Wnt signaling, Inflammation, Chemoprevention

Core tip: Epidemiological studies suggest that deficiency of vitamin D increases the incidence of colon cancer and also has a negative impact on the survival of colon cancer patients. The ability of 1,25D₃ to interfere with Wnt signaling and to ameliorate inflammation is likely to contribute to its anticancer activity.