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World J Gastrointest Oncol. Nov 15, 2014; 6(11): 430-437
Published online Nov 15, 2014. doi: 10.4251/wjgo.v6.i11.430
Vitamin D and colon cancer
Lidija Klampfer
Lidija Klampfer, Southern Research Institute, Birmingham, AL 35205, United States
Author contributions: Klampfer L solely contributed to this paper.
Correspondence to: Lidija Klampfer, PhD, Southern Research Institute, 2000 9th Avenue, Birmingham, AL 35205, United States.
Telephone: +1-205-5812731
Received: May 22, 2014
Revised: July 31, 2014
Accepted: September 23, 2014
Published online: November 15, 2014
Core Tip

Core tip: Epidemiological studies suggest that deficiency of vitamin D increases the incidence of colon cancer and also has a negative impact on the survival of colon cancer patients. The ability of 1,25D3 to interfere with Wnt signaling and to ameliorate inflammation is likely to contribute to its anticancer activity.