Published online Nov 15, 2014. doi: 10.4251/wjgo.v6.i11.430
Revised: July 31, 2014
Accepted: September 23, 2014
Published online: November 15, 2014
Core tip: Epidemiological studies suggest that deficiency of vitamin D increases the incidence of colon cancer and also has a negative impact on the survival of colon cancer patients. The ability of 1,25D3 to interfere with Wnt signaling and to ameliorate inflammation is likely to contribute to its anticancer activity.