Jiang Y, Xu SH, Han L, Lu N, Huang S, Wang L. Accuracy of dual-contrast gastrointestinal ultrasonography in predicting lymph node metastasis in older adults with gastric cancer. World J Gastrointest Oncol 2025; 17(5): 104194 [DOI: 10.4251/wjgo.v17.i5.104194]
Corresponding Author of This Article
Lei Wang, Associate Chief Physician, Department of Ultrasound, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Suzhou Industrial Park, No. 9 Chongwen Road, Suzhou 215000, Jiangsu Province, China. wang13382198185@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Oncol. May 15, 2025; 17(5): 104194 Published online May 15, 2025. doi: 10.4251/wjgo.v17.i5.104194
Accuracy of dual-contrast gastrointestinal ultrasonography in predicting lymph node metastasis in older adults with gastric cancer
Yue Jiang, Shao-Hua Xu, Li Han, Na Lu, Shuai Huang, Lei Wang
Yue Jiang, Na Lu, Shuai Huang, Lei Wang, Department of Ultrasound, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Suzhou 215000, Jiangsu Province, China
Shao-Hua Xu, Li Han, Department of Ultrasound, Shanghai Jiao Tong University School of Medicine Suzhou Jiulong Hospital, Suzhou 215000, Jiangsu Province, China
Author contributions: Jiang Y designed the study; Jiang Y, Xu SH, Han L, Lu N, Huang S, and Wang L contributed to the analysis; Jiang Y and Xu SH contributed to data acquisition and manuscript writing; all authors have read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital; No. 2024 Lunyan Approval 241098).
Informed consent statement: All study participants and their legal guardians provided written informed consent before recruitment.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lei Wang, Associate Chief Physician, Department of Ultrasound, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Suzhou Industrial Park, No. 9 Chongwen Road, Suzhou 215000, Jiangsu Province, China. wang13382198185@126.com
Received: March 5, 2025 Revised: March 30, 2025 Accepted: April 15, 2025 Published online: May 15, 2025 Processing time: 71 Days and 3.1 Hours
Abstract
BACKGROUND
Gastrointestinal dual-contrast ultrasonography (DCUS) is characterized by its high resolution, sensitivity, and specificity.
AIM
To determine the accuracy of DCUS in predicting lymph node metastasis in middle-aged and elderly patients with gastric cancer (GC).
METHODS
A total of 100 middle-aged and elderly patients with GC admitted to the Fourth Affiliated Hospital of Soochow University (Dushu Lake Hospital, Suzhou, China) between April 2022 and April 2024 were selected. The baseline data and lymph node metastasis status were collected. DCUS combined with intravenous contrast technology was used to calculate the enhancement time (ET), time to peak (TTP), and slope of the ascending branch wash-in rate (WIR). These indicators were used in assessing lymph node metastasis in patients with GC.
RESULTS
Among 100 middle-aged and elderly patients with GC, 35 (35.00%) had lymph node metastases. GC patients with lymph node metastasis had a higher proportion of stage II TNM classification and higher WIR values than those without lymph node metastasis. The ET and TTP values were lower in patients with lymph node metastases, and all differences were statistically significant (P < 0.05). The area under the curve values for ET, TTP, WIR, and combined diagnosis of GC lymph node metastasis using DCUS were all > 0.7. Optimal assessment was achieved when the cutoff values for ET, TTP, and WIR were set at 16.32 seconds, 10.67 seconds, and 7.02, respectively.
CONCLUSION
DCUS-mediated assessment of ET, TTP, and WIR can effectively predict and evaluate lymph node metastasis status in patients with GC, with higher sensitivity when used in combination.
Core Tip: Accurate assessment of lymph node metastasis is crucial for middle-aged and elderly patients with gastric cancer (GC), and dual-contrast ultrasonography can effectively predict and evaluate lymph node metastasis status in GC patients.
