Scientometrics
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. May 15, 2024; 16(5): 2181-2199
Published online May 15, 2024. doi: 10.4251/wjgo.v16.i5.2181
Mapping the intellectual structure and emerging trends for the application of nanomaterials in gastric cancer: A bibliometric study
Bo-Na Liu, Xiao-Li Gao, Ying Piao
Bo-Na Liu, Xiao-Li Gao, Ying Piao, Department of Oncology, General Hospital of Northern Theater Command, Shenyang 110015, Liaoning Province, China
Author contributions: Liu BN wrote the paper; Gao XL and Piao Y revised the manuscript; Piao Y conceived and designed this study.
Conflict-of-interest statement: The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying Piao, MD, PhD, Professor, Department of Oncology, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, Shenyang 110015, Liaoning Province, China. y_13654908253@163.com
Received: November 24, 2023
Peer-review started: November 24, 2023
First decision: January 19, 2024
Revised: February 11, 2024
Accepted: March 21, 2024
Article in press: March 21, 2024
Published online: May 15, 2024
Abstract
BACKGROUND

Recent reviews have outlined the main nanomaterials used in relation to gastrointestinal tumors and described the basic properties of these materials. However, the research hotspots and trends in the application of nanomaterials in gastric cancer (GC) remain obscure.

AIM

To demonstrate the knowledge structure and evolutionary trends of research into the application of nanomaterials in GC.

METHODS

Publications related to the application of nanomaterials in GC were retrieved from the Web of Science Core Collection for this systematic review and bibliometric study. VOSviewer and CiteSpace were used for bibliometric and visualization analyses.

RESULTS

From 2000 to 2022, the application of nanomaterials in GC developed rapidly. The keyword co-occurrence analysis showed that the related research topics were divided into three clusters: (1) The application of nanomaterials in GC treatment; (2) The application and toxicity of nanomaterials in GC diagnosis; and (3) The effects of nanomaterials on the biological behavior of GC cells. Complexes, silver nanoparticles, and green synthesis are the latest high-frequency keywords that represent promising future research directions.

CONCLUSION

The application of nanomaterials in GC diagnosis and treatment and the mechanisms of their effects on GC cells have been major themes in this field over the past 23 years.

Keywords: Nanomaterials, Gastric cancer, Bibliometrics, Drug delivery, VOSviewer, CiteSpace, Systematic review

Core Tip: From 2000 to 2022, the application of nanomaterials in gastric cancer (GC) developed rapidly. The keywords co-occurrence analysis showed that the related research topics were divided into three clusters: (1) The application of nanomaterials in GC treatment; (2) The application and toxicity of nanomaterials in GC diagnosis; and (3) The effect of nanomaterials on the biological behavior of GC cells. Complexes, silver nanoparticles, and green synthesis were the latest high-frequency keywords that represent promising future research directions. Thus, the application of nanomaterials in GC diagnosis and treatment; and the mechanisms of their effects on GC cells have been major themes in this field over the past 23 years.