Case Report
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2019; 11(12): 1231-1239
Published online Dec 15, 2019. doi: 10.4251/wjgo.v11.i12.1231
Inflammatory pseudotumor-like follicular dendritic cell sarcoma: A brief report of two cases
Bi-Xi Zhang, Zhi-Hong Chen, Yu Liu, Yuan-Jun Zeng, Yan-Chun Li
Bi-Xi Zhang, Zhi-Hong Chen, Yu Liu, Yuan-Jun Zeng, Yan-Chun Li, Department of Pathology, People’s Hospital of Hunan Province, Changsha 410005, Hunan Province, China
Author contributions: All authors contributed to the study; Zhang BX wrote the manuscript; Chen ZH, Liu Y, Zeng YJ, and Li YC collected and analysed the data and contributed to the follow-up results; all authors read and approved the final manuscript.
Informed consent statement: All study participants, or their legal guardian, provided written informed consent prior to the study.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yan-Chun Li, PhD, Doctor, Department of Pathology, People’s Hospital of Hunan Province, No. 61, Jiefang West Road, Changsha 410005, Hunan Province, China. lychglx@163.com
Telephone: +86-731-83929288
Received: February 20, 2019
Peer-review started: February 22, 2019
First decision: June 4, 2019
Revised: September 1, 2019
Accepted: September 26, 2019
Article in press: September 26, 2019
Published online: December 15, 2019
Abstract
BACKGROUND

Follicular dendritic cell (FDC) sarcoma/tumor is a rare malignant tumor of follicular dendritic cells, which is considered a low-grade sarcoma that can involve lymph nodes or extranodal sites. Conventional FDC sarcomas are negative for Epstein-Barr virus (EBV), whereas the inflammatory pseudotumor-like variant consistently shows EBV in the neoplastic cells.

CASE SUMMARY

We report two cases of inflammatory pseudotumor-like FDC sarcoma in the liver that received 3D laparoscopic right hepatectomy and open right hepatectomy separately.

CONCLUSION

EBV probe-based in situ hybridization and detection of immunohistochemical markers of FDC play an important role in the diagnosis and differential diagnosis of inflammatory pseudotumor-like FDC sarcoma. Complete surgical excision combined with regional lymphadenectomy may be effective in reducing the postoperative recurrence and metastasis and improving long-term survival rates.

Keywords: Inflammatory pseudotumor-like follicular dendritic cell sarcoma, Epstein-Barr virus, Liver, Spleen, Case report

Core tip: There have been 48 previously reported cases of inflammatory pseudotumor-like follicular dendritic cell (FDC) sarcoma, which occurs almost exclusively in the liver and spleen. Here we report two cases of inflammatory pseudotumor-like FDC sarcoma in the liver that were treated by 3D laparoscopic right hepatectomy and open right hepatectomy separately.