Published online Apr 16, 2014. doi: 10.4253/wjge.v6.i4.137
Revised: March 4, 2014
Accepted: March 11, 2014
Published online: April 16, 2014
Core tip: Endoscopic retrograde cholangiography remains the gold standard method for diagnosing biliary tract diseases. However, choledochoscopy with the SpyGlassTM system enables direct visualization of the biliary tract. Furthermore, targeted biopsies can be performed. In our single-center study, the diagnostic yield of SpyGlassTM-directed biopsy for inflammatory changes in primary sclerosing cholangitis (PSC) and non-PSC patients was significantly greater than that of brush cytology. The better diagnostic yield strongly correlated with significantly greater amounts of tissue for histological evaluation.