Systematic Reviews
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Endosc. Mar 16, 2022; 14(3): 163-175
Published online Mar 16, 2022. doi: 10.4253/wjge.v14.i3.163
Endoscopic management and outcome of non-variceal bleeding in patients with liver cirrhosis: A systematic review
Georgios Demetriou, Aikaterini Augoustaki, Evangelos Kalaitzakis
Georgios Demetriou, Aikaterini Augoustaki, Evangelos Kalaitzakis, Department of Gastroenterology, University Hospital of Heraklion, Heraklion 71500, Greece
Author contributions: Kalaitzakis E conceived the idea of the topic and designed the project with Demetriou G; Demetriou G and Augoustaki A searched and screened the titles and abstracts of all relative studies and then full text of the most relevant ones for eligibility criteria; any disagreement was resolved by means of consensus with all authors; all authors contributed to the selection of the studies and interpretation of the results; Demetriou G and Kalaitzakis E wrote the manuscript while Augoustaki A aided in revision; all authors discussed the results and made comments on the manuscript.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Georgios Demetriou, Doctor, Department of Gastroenterology, University Hospital of Heraklion, Panepistimiou, Voutes, Heraklion 71500, Greece.
Received: June 30, 2021
Peer-review started: June 30, 2021
First decision: September 29, 2021
Revised: October 8, 2021
Accepted: February 10, 2022
Article in press: February 10, 2022
Published online: March 16, 2022
Core Tip

Core Tip: Acute non-variceal gastrointestinal bleeding (ANVGIB) is not uncommon in cirrhotic patients. Survival of these patients has improved in recent years due to the evolution of both endoscopic and pharmacologic treatment. However data on most sources of ANVGIB and the efficacy of endoscopic therapy in cirrhosis are very limited, while similar data on acute bleeding from the lower gastrointestinal tract are almost non-existent in this group of patients. We herein present endoscopic modalities used to control ANVGIB and post-treatment outcomes in patients with liver cirrhosis. Our review highlights that endoscopic therapy seems to be effective in these patients, although comparative data with non-cirrhotic patients are very few.