Published online Oct 16, 2021. doi: 10.4253/wjge.v13.i10.460
Peer-review started: March 29, 2021
First decision: June 17, 2021
Revised: June 27, 2021
Accepted: September 8, 2021
Article in press: September 8, 2021
Published online: October 16, 2021
Core Tip: In this review, we analyzed the efficacy of the celiac plexus neurolysis through echoendoscopy (EUS-CPN) technique in patients with unresectable pancreatic cancer. The use of opioids for pain control are associated with numerous side effects that reduce the quality of life of pancreatic cancer patients, and the use of EUS-CPN is a safe and effective approach to pain management and allows for the reduction in the opioid doses used. There are different techniques to perform a EUS-CPN, all of which are described in this article. However, there are concerns about the efficacy of EUS-CPN (since it produces a reduction in pain for a short time), the ideal time to perform this technique is unknown, and it is also unknown whether this technique has any influence on patient survival and quality of life.