Published online Nov 16, 2022. doi: 10.4253/wjge.v14.i11.704
Peer-review started: September 2, 2022
First decision: September 19, 2022
Revised: September 23, 2022
Accepted: October 25, 2022
Article in press: October 25, 2022
Published online: November 16, 2022
Experimental studies suggest that self-expanding metal stents (SEMSs) enhance the aggressive behavior of obstructive colorectal cancer.
The influence of SEMS placement on pathological alterations remains to be elucidated.
This study aimed to determine whether SEMS placement is associated with molecular or pathological features of colorectal carcinoma tissues.
Using a nonbiased molecular pathological epidemiology database of patients with obstructive colorectal cancers, we examined the association of SEMS placement with molecular or pathological feature.
SEMS placement was significantly associated with venous invasion (P < 0.01), but not with the other features examined, including tumor size, disease stage, mutation status, and lymphatic invasion. In both the univariable and mult
SEMS placement might be associated with severe venous invasion in colorectal cancer tissue.
Future studies are needed to confirm our findings and examine the association of SEMS placement with pathological features and long-term survival of patients with obstructive colorectal cancer.