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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Self-expanding metal stent placement and pathological alterations among obstructive colorectal cancer cases
Keisuke Kosumi, Kosuke Mima, Kosuke Kanemitsu, Takuya Tajiri, Toru Takematsu, Yuki Sakamoto, Mitsuhiro Inoue, Yuji Miyamoto, Takao Mizumoto, Tatsuo Kubota, Nobutomo Miyanari, Hideo Baba
Keisuke Kosumi, Department of Gastroenterological Surgery, Kumamoto University, Kuma- moto 860-8556, Japan
Kosuke Mima, Yuki Sakamoto, Mitsuhiro Inoue, Takao Mizumoto, Tatsuo Kubota, Nobutomo Miyanari, Department of Surgery, National Hospital Organization Kumamoto Medical Center, Kumamoto 860-0008, Japan
Kosuke Kanemitsu, Takuya Tajiri, Toru Takematsu, Yuji Miyamoto, Hideo Baba, Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Honjo 860-8556, Kumamoto, Japan
Author contributions: Kosumi K, Mima K, Miyanari N and Baba H participated in study conception and design; All authors participated in data acquisition; Kosumi K and Mima K performed the statistical analyses and analyzed the data; Miyanari N and Baba H supervised the work; Kosumi K, Mima K, Miyamoto Y, Miyanari N and Baba H were the major contributors to manuscript preparation; All authors contributed to the manuscript, critically revised it, and approved the final version.
Institutional review board statement: This study was approved by the Human Ethics Review Committee of the National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan, No. 1061.
Informed consent statement: The requirement for written informed consent was waived in view of the retrospective nature of the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The analysis used anonymous clinical data.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Keisuke Kosumi, MD, PhD, Doctor, Surgeon, Surgical Oncologist, Department of Gastroenterological Surgery, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan. kosumi-kmm@umin.ac.jp
Received: September 2, 2022
Peer-review started: September 2, 2022
First decision: September 19, 2022
Revised: September 23, 2022
Accepted: October 25, 2022
Article in press: October 25, 2022
Published online: November 16, 2022
ARTICLE HIGHLIGHTS
Research background
Experimental studies suggest that self-expanding metal stents (SEMSs) enhance the aggressive behavior of obstructive colorectal cancer.
Research motivation
The influence of SEMS placement on pathological alterations remains to be elucidated.
Research objectives
This study aimed to determine whether SEMS placement is associated with molecular or pathological features of colorectal carcinoma tissues.
Research methods
Using a nonbiased molecular pathological epidemiology database of patients with obstructive colorectal cancers, we examined the association of SEMS placement with molecular or pathological feature.
Research results
SEMS placement was significantly associated with venous invasion (P < 0.01), but not with the other features examined, including tumor size, disease stage, mutation status, and lymphatic invasion. In both the univariable and multivariable models with adjustment for potential factors including tumor location, histological type, and American Joint Committee on Cancer-pT stage, SEMS placement was significantly associated with severe venous invasion (P < 0.01).
Research conclusions
SEMS placement might be associated with severe venous invasion in colorectal cancer tissue.
Research perspectives
Future studies are needed to confirm our findings and examine the association of SEMS placement with pathological features and long-term survival of patients with obstructive colorectal cancer.
