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©The Author(s) 2018.
World J Hepatol. Jan 27, 2018; 10(1): 73-81
Published online Jan 27, 2018. doi: 10.4254/wjh.v10.i1.73
Published online Jan 27, 2018. doi: 10.4254/wjh.v10.i1.73
Table 1 Patients characteristics
| Variable | Controls (n = 9) | Alcohol abstinents (n = 20) | Active alcohol drinkers (n = 41) | P value (abstinent vs active alcohol drinkers) |
| Age (yr) | 38.2 (35-49) | 59.5 (55-65) | 56.9 (52-63) | 0.40 |
| Male sex | 6 (67%) | 16 (80%) | 33 (80%) | 1.0 |
| Ascites | 0 | 11 (61%) | 23 (64%) | 1.0 |
| HE | 0 | 3 (16%) | 7 (21%) | 1.0 |
| Esophageal varices | 0 | 15 (83%) | 25 (69%) | 0.30 |
| HVPG (mmHg) | 2 (2-3) | 18 (16-19) | 18 (14-20) | 0.90 |
| Liver stiffness (kPa) | 3.8 (3-3.8) | Not available | 38.6 (14.6-68.2) | - |
| Platelet count (G/L) | 286 (170-340) | 44.5 (20-55) | 33.5 (20-53) | 0.40 |
| Child-Pugh score | - | 9.5 (8-10) | 9 (8-11) | 0.94 |
| MELD score | - | 14 (12-19) | 19 (11-22) | 0.50 |
Table 2 Histological features on transjugular liver biopsy
| Variable | Controls (n = 9) | Alcohol abstinents (n = 20) | Active alcohol drinkers (n = 41) | P value (abstinent vs active alcohol drinkers) |
| Cirrhosis | 0 (9%) | 20 (100%) | 41 (100%) | 1.0 |
| Marked steatosis | 0 (0%) | 1 (5%) | 21 (51%) | 0.001 |
| Marked ballooned hepatocytes | 0 (0%) | 5 (26%) | 25 (64%) | 0.01 |
| Marked inflammation | 0 (0%) | 0 (0%) | 1 (2%) | 0.9 |
| Fibrosis density (%) | 0.7 (0.2-1.5) | 3.8 (1.1-11.8) | 8.2 (3.8-14.1) | 0.17 |
| Fibrosis category | 0.48 | |||
| 0%-5% | 9 | 11 | 15 | |
| 5%-10% | 0 | 3 | 9 | |
| 10%-20% | 0 | 3 | 12 | |
| > 20% | 0 | 3 | 5 |
Table 3 Characteristics of patients with alcoholic liver disease according to fibrosis density
| Variable | Fibrosis density ≤ 5% (n = 26) | Fibrosis density > 5% (n = 35) | P value |
| Active alcohol | 15 (58%) | 26 (74%) | 0.27 |
| Age (yr) | 58 (55-64) | 57 (52-63) | 0.4 |
| Male sex | 24 (92%) | 25 (71%) | 0.06 |
| Ascites | 12 (55%) | 22 (69%) | 0.4 |
| HE | 7 (32%) | 3 (10%) | 0.07 |
| Esophageal varices | 15 (65%) | 25 (81%) | 0.2 |
| HVPG (mmHg) | 16 (11-18) | 19 (17-20) | 0.01 |
| Liver stiffness (kPa) | 19 (12-42) | 57 (34-72) | 0.5 |
| Platelet count (G/L) | 37 (20-52) | 38 (20-55) | 0.7 |
| MELD score | 14 (11-19) | 18 (13-22) | 0.2 |
| Histology | |||
| Marked steatosis | 11 (42%) | 11 (31%) | 0.4 |
| Marked ballooned hepatocytes | 9 (36%) | 21 (64%) | 0.06 |
| Marked inflammation | 0 (0%) | 1 (3%) | 0.9 |
- Citation: Restellini S, Goossens N, Clément S, Lanthier N, Negro F, Rubbia-Brandt L, Spahr L. Collagen proportionate area correlates to hepatic venous pressure gradient in non-abstinent cirrhotic patients with alcoholic liver disease. World J Hepatol 2018; 10(1): 73-81
- URL: https://www.wjgnet.com/1948-5182/full/v10/i1/73.htm
- DOI: https://dx.doi.org/10.4254/wjh.v10.i1.73