Factors associated with success of telaprevir- and boceprevir-based triple therapy for hepatitis C virus infection
Kian Bichoupan, Neeta Tandon, Valerie Martel-Laferriere, Neal M Patel, David Sachs, Michel Ng, Emily A Schonfeld, Alexis Pappas, James Crismale, Alicia Stivala, Viktoriya Khaitova, Donald Gardenier, Michael Linderman, William Olson, Ponni V Perumalswami, Thomas D Schiano, Joseph A Odin, Lawrence U Liu, Douglas T Dieterich, Andrea D Branch, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, Icahn Medical Instititute, New York, NY 10029, United States
Neeta Tandon, William Olson, Janssen Pharmaceuticals Companies, Division of Janssen Scientific Affairs Inc., Titusville, NJ 08560, United States
David Sachs, Michael Linderman, Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
Author contributions: Bichoupan K, Tandon N, Olson W and Branch AD designed the research; Bichoupan K and Martel-Laferriere V performed the research; Bichoupan K analyzed the data; Bichoupan K, Tandon N, Martel-Laferriere V, Patel NM, Sachs D, Ng M, Schonfeld EA, Pappas A, Crismale J, Stivala A, Khaitova V, Gardenier D, Linderman M, Olson W, Perumalswami PV, Schiano TD, Odin JA, Liu LU, Dieterich DT and Branch AD revised and edited the manuscript.
Supported by Janssen Scientific Affairs, LLC (partially) to Andrea D Branch to conduct the study; National Institute of Health (NIH), Nos. DK090317 and DA031095 (partially) to Andrea D Branch to conduct the study.
Institutional review board statement: The study was reviewed at approved by the Icahn School of Medicine at Mount Sinai Institutional Review Board.
Informed consent statement: Study participants did not provide informed consent prior to study enrollment as the Icahn School of Medicine at Mount Sinai Institutional Review Board provided a waiver of authorization to release deidentified patient data for research purposes.
Conflict-of-interest statement: Kian Bichoupan is a paid consultant for Gilead Sciences and Janssen Pharmaceuticals, Inc. Dr. Andrea D Branch is a paid consultant for Gilead Sciences and Janssen Pharmaceuticals, Inc. Dr. Douglas T Dieterich serves as a paid lecturer, consultant and is a member on scientific advisory boards of companies which either develop or assess medicines used for the treatment of viral hepatitis. These companies include Gilead Sciences, Abbvie, Achillion, Bristol-Myers Squibb, Merck, and Janssen Pharmaceuticals, Inc. Dr. Thomas D Schiano is a paid consultant for Salix, Merck, Gilead, BMS, Novartis and Janssen and received research support from Mass biologics, Gilead, Merck, Biotest and Genentech. Michel Ng is a paid member of AbbVie’s Speakers bureau. Viktoriya Khaitova is a paid member of a scientific advisory board for Abbvie, and Johnson & Johnson. Dr. Valerie Martel-Lafferiere, Dr. Emily A Schonfeld, Dr. James Crismale, Alicia Stivala, Donald Gardenier, Dr. David Sachs, Dr. Joseph A. Odin, Dr. Lawrence Liu, Dr. Neal M Patel, and Dr. Ponni V Perumalswami do not have any disclosures.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at email@example.com. Consent was not obtained but the presented data are anonymized and risk of identification is low.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Kian Bichoupan, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, Icahn Medical Instititute, 11th floor, Room 34, 1425 Madison Avenue, New York, NY 10029, United States. firstname.lastname@example.org
Telephone: +1-516-5671126 Fax: +1-212-8492574
Received: June 22, 2015
Peer-review started: June 23, 2015
First decision: September 21, 2015
Revised: February 10, 2017
Accepted: March 14, 2017
Article in press: March 17, 2017
Published online: April 18, 2017