Factors associated with success of telaprevir- and boceprevir-based triple therapy for hepatitis C virus infection

Table 1 Baseline characteristics of the study group

	n	Continuous variables: Median (IQR)/categorical variables: n (%)	Range
Telaprevir	223	172 (77)	-
Demographics and anthropometrics
Age, yr	223	57 (51-61)	22-74
Gender, male	223	144 (65)	-
Race, white	223	182 (82)	-
BMI, kg/m3, 17-24: Normal; 25-30: Overweight; > 30: Obesea	186	27.1 (24.5-30.7)	16.3-49.3
Past medical history
Diabetes	223	48 (22)	-
Depression	223	47 (21)	-
IL28B genotype	223
CC		20 (9)	-
CT		50 (22)	-
TT		21 (10)	-
Unknown		132 (59)	-
Treatment history	223
Naïve		68 (31)	-
Non-responder		95 (43)	-
Relapser		45 (20)	-
Intolerance		12 (5)	-
Unknown		3 (1)	-
HCV treatment related characteristics
HCV viral load, log IU/mL	221	6.31 (5.89-6.66)	3.07-7.64
Sub-genotype	223
1a		118 (53.5)	-
1b		72 (32)	-
1a/1b		1 (0.5)	-
Unknown		32 (14)	-
Laboratory tests
Hemoglobin, g/dL, female:12-15.5 g/dL; male: 13.5-17.5 g/dLa	220	14.3 (13.2-15.3)	9.2-18.2
AFP, ng/mL, 1.6-4.5 ng/mLa	158	6.85 (3.58-13.83)	0.80-208.60
Albumin g/dL, 3.5-4.9 g/dLa	219	4.20 (3.90-4.50)	2.60-5.30
AST, U/L, 1-50 U/La	221	62 (39-106)	19-324
ALT, U/L, 1-53 U/La	221	67 (44-107)	15-403
Platelets, × 103/μL, 150-450 × 103/μLa	223	152 (106-195)	14-365
Creatinine, mg/dL, 0.60-1.40 mg/dLa	205	0.91 (0.81-1.04)	0.58-10.2
Ferritin, ng/mL, 15-150 ng/mLa	54	184 (113-373)	22-893
eGFR, mL/min/1.73 m2 < 60 mL/min per 1.73 m2ab	204	88 (75-99)	6-125
Indication of liver fibrosis
APRI score	221	0.82 (0.43-1.82)	0.10-12.48
FIB-4 score	221	2.65 (1.77-5.66)	0.35-35.30
FIB-4, advanced fibrosis/cirrhosisc	221	98/221 (44)	-
Cirrhosis, biopsy	189	85/189 (45)	-
Transient elastography score, kPa	80	11.8 (7.2-20.3)	3.9-55.1
Cirrhosis, transient elastographyd	80	36/80 (45)	-
Cirrhosis, transient elastography/biopsy	202	96/202 (48)	-

^aNormal range;

^bEstimated glomerular filtration rate calculated with epidemiology formula;

^cFIB-4 score ≥ 3.25 kPa;

^dTransient elastography > 13.5 kPa. BMI: Body mass index; HCV: Hepatitis C virus; AFP: Alpha-fetoprotein; AST: Aspartate transaminase; ALT: Alanine transaminase; eGFR: Estimated glomerular filtration rate; APRI: Aspartate transaminase to platelet ratio index.