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World J Hepatol. Aug 28, 2017; 9(24): 1022-1029
Published online Aug 28, 2017. doi: 10.4254/wjh.v9.i24.1022
Liver transplantation in the treatment of severe iatrogenic liver injuries
Andrea Lauterio, Riccardo De Carlis, Stefano Di Sandro, Fabio Ferla, Vincenzo Buscemi, Luciano De Carlis
Andrea Lauterio, Riccardo De Carlis, Stefano Di Sandro, Fabio Ferla, Vincenzo Buscemi, Luciano De Carlis, Division of General Surgery and Abdominal Transplantation, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy
Riccardo De Carlis, Vincenzo Buscemi, Department of Surgical Sciences, University of Pavia, 27100 Pavia, Italy
Stefano Di Sandro, Department of Experimental Medicine, University of Pavia, 27100 Pavia, Italy
Luciano De Carlis, School of Medicine, University of Milan-Bicocca, 20162 Milan, Italy
Author contributions: Lauterio A drafted the article critically for important intellectual content; Di Sandro S, De Carlis R, Ferla F and Buscemi V gave substantial contributions to concept of the article and acquisition of data; Lauterio A and De Carlis L gave the final approval of the version to be published.
Conflict-of-interest statement: No conflict of interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Andrea Lauterio, MD, FEBS, Division of General Surgery and Abdominal Transplantation, ASST Grande Ospedale Metropolitano Niguarda, Piazza Ospedale Maggiore, 20162 Milan, Italy. andrea.lauterio@ospedaleniguarda.it
Telephone: +39-2-64444673 Fax: +39-2-64443319
Received: February 28, 2017
Peer-review started: March 2, 2017
First decision: May 3, 2017
Revised: May 19, 2017
Accepted: July 14, 2017
Article in press: July 17, 2017
Published online: August 28, 2017
Core Tip

Core tip: Liver transplantation may represent the only option to manage severe iatrogenic liver injuries. Despite widespread interest, reported experiences indicate only a minority of liver transplants are performed, and the place of liver transplantation in this setting has not yet been widely discussed. Causes other than severe bile duct injuries during cholecystectomy are less common indications for liver transplantation. Urgent liver transplantation for the treatment of severe iatrogenic liver injury may require technically difficult and time-consuming surgical procedures. The centralization of complex surgery in tertiary centers and the early referral of patients with severe iatrogenic liver injuries are crucial.