Published online Mar 27, 2014. doi: 10.4254/wjh.v6.i3.137
Revised: November 5, 2013
Accepted: January 15, 2014
Published online: March 27, 2014
Core tip: Liver innervation comprises sympathetic, parasympathetic and peptidergic nerve fibers, organized as either afferent or efferent nerves with different origins and roles. Their anatomy and physiology have been studied in the past 30 years, with different results published over time. Hepatocytes are the main cell population of the liver, making up almost 80% of the total liver volume. The interaction between hepatocytes and nerve fibers is accomplished through a wealth of neurotransmitters and signaling pathways.