Published online Oct 27, 2013. doi: 10.4254/wjh.v5.i10.558
Revised: September 23, 2013
Accepted: October 11, 2013
Published online: October 27, 2013
Core tip: We describe a new method to quantify lipid classes in steatosis/steatohepatitis having advantages over both histology and classical analytical methods. Since lipid classes exert differential pathophysiological actions our method should be of interest for all researchers dealing with mechanisms of steatosis and steatohepatitis. We employ our method to investigate the lipid profile in the steatotic p62 transgenic mouse model. p62 was originally identified as an autoantigen overexpressed in hepatocellular carcinoma patients, its expression correlates with poor prognosis, and it induces steatosis. The interesting lipid profile in p62 transgenic animals suggests that it might advance the step from steatosis towards steatohepatitis.