Hepatocyte-intrinsic innate immunity in hepatitis B virus infection: A focused review

doi:10.4254/wjh.v17.i6.104533

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Jun 27, 2025 (publication date) through Jun 25, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jun 27, 2025; 17(6): 104533
Published online Jun 27, 2025. doi: 10.4254/wjh.v17.i6.104533

Hepatocyte-intrinsic innate immunity in hepatitis B virus infection: A focused review

Ping Chen, Jing Zhao, Ning-Kai Chen, Zhi-Ying Chen

Ping Chen, Ning-Kai Chen, Zhi-Ying Chen, Department of Research and Development, Syno Minicircle Biotechnology Co. Ltd., Shenzhen 518107, Guangdong Province, China

Jing Zhao, Scientific Research Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen 518107, Guangdong Province, China

Co-corresponding authors: Ping Chen and Zhi-Ying Chen.

Author contributions: Chen P designed the structure of this review and wrote the manuscript; Chen P, Chen NK and Chen ZY revised the manuscript; Zhao J contributed to the literature collection; All authors read and approved the final manuscript.

Supported by Shenzhen Medical Research Fund, No. D2301010; and Shenzhen Science and Technology Program, No. RCYX20231211090346060.

Conflict-of-interest statement: The authors declare no conflict of interests for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ping Chen, PhD, Department of Research and Development, Syno Minicircle Biotechnology Co. Ltd., A1003, Gaoke Innovation Center, Guangqiao Road, Guangming District, Shenzhen 518107, Guangdong Province, China. pingchen09@gmail.com

Received: December 25, 2024
Revised: April 17, 2025
Accepted: June 4, 2025
Published online: June 27, 2025
Processing time: 183 Days and 3.6 Hours

Core Tip

Core Tip: Despite the advancements in hepatitis B virus (HBV) immunology, the mechanism by which hepatocytes exert their innate immune responses against HBV infection remains poorly understood. This article focused on the complex interplay between hepatocytes and the innate immune response during HBV infection and summarized the recent findings about how HBV evading the innate response to promoter viral persistence. These insights may be helpful for developing novel anti-HBV immune-based therapies.