Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Sep 27, 2023; 15(9): 1060-1083
Published online Sep 27, 2023. doi: 10.4254/wjh.v15.i9.1060
Corrected QT interval in cirrhosis: A systematic review and meta-analysis
Vasileios Periklis Papadopoulos, Konstantinos Mimidis
Vasileios Periklis Papadopoulos, Dialysis, AKESIOS Dialysis Center, Xanthi 67150, Greece
Konstantinos Mimidis, First Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis 68100, Greece
Author contributions: Papadopoulos VP contributed to design of the study; Papadopoulos VP and Mimidis K contributed to conception of the study, acquisition, analysis and interpretation of the data, and drafting of the manuscript; and all authors gave final approval of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Vasileios Periklis Papadopoulos, MD, MSc, PhD, Consultant Physician-Scientist, Research Fellow, Dialysis, AKESIOS Dialysis Center, Vaniano, Xanthi 67150, Greece.
Received: July 16, 2023
Peer-review started: July 16, 2023
First decision: August 4, 2023
Revised: August 13, 2023
Accepted: August 29, 2023
Article in press: August 29, 2023
Published online: September 27, 2023
Core Tip

Core Tip: Corrected QT (QTc) interval is prolonged in patients with liver cirrhosis and has been proposed to correlate with the severity of the disease. The QTc upper normal limit in cirrhosis is widely debated. Moreover, the effects of sex, age, Child-Pugh stage, model for end-stage liver disease score, and etiology of cirrhosis have not been elucidated, while the role of liver transplantation has been largely unknown. The present study is the first systematic review and meta-analysis focusing on the topics mentioned above, thus aiming to determine whether QTc interval is a useful, easy, and inexpensive tool in the assessment of liver cirrhosis by clinicians.