Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Sep 27, 2023; 15(9): 1060-1083
Published online Sep 27, 2023. doi: 10.4254/wjh.v15.i9.1060
Corrected QT interval in cirrhosis: A systematic review and meta-analysis
Vasileios Periklis Papadopoulos, Konstantinos Mimidis
Vasileios Periklis Papadopoulos, Dialysis, AKESIOS Dialysis Center, Xanthi 67150, Greece
Konstantinos Mimidis, First Department of Internal Medicine, Democritus University of Thrace, Alexandroupolis 68100, Greece
Author contributions: Papadopoulos VP contributed to design of the study; Papadopoulos VP and Mimidis K contributed to conception of the study, acquisition, analysis and interpretation of the data, and drafting of the manuscript; and all authors gave final approval of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Vasileios Periklis Papadopoulos, MD, MSc, PhD, Consultant Physician-Scientist, Research Fellow, Dialysis, AKESIOS Dialysis Center, Vaniano, Xanthi 67150, Greece.
Received: July 16, 2023
Peer-review started: July 16, 2023
First decision: August 4, 2023
Revised: August 13, 2023
Accepted: August 29, 2023
Article in press: August 29, 2023
Published online: September 27, 2023
Research background

The effects of sex, age, severity, and etiology, as well as the role of treatment, acute illness, and liver transplantation (Tx) are largely unknown regarding corrected QT (QTc) in cirrhosis.

Research motivation

It is unknown whether QTc is prolonged in patients with cirrhosis and whether QTc is affected by factors such as sex, age, severity, etiology, regimens, acute illness, and liver Tx.

Research objectives

To investigate QTc clinical usefulness in cirrhosis.

Research methods

Seventy-three studies were considered eligible, as identified by application of the search protocol “{[QTc] OR [QT interval] OR [QT-interval] OR [Q-T syndrome]} AND {[cirrhosis] OR [Child-Pugh] OR [MELD]}” in PubMed, EMBASE, and Google Scholar databases.

Research results

QTc was prolonged in patients with cirrhosis independent of sex and age (444.8 ± 4.4 ms). QTc correlated with Child-Pugh stage and model for end-stage liver disease score. QTc improved after liver Tx.

Research conclusions

QT prolongation in cirrhosis is independent of sex and age, is aggravated in severe cases, and benefited by liver Tx.

Research perspectives

QTc interval could be further evaluated as a tool in the assessment of liver cirrhosis by clinicians.