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Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Aug 27, 2023; 15(8): 954-963
Published online Aug 27, 2023. doi: 10.4254/wjh.v15.i8.954
Prognostic and diagnostic scoring models in acute alcohol-associated hepatitis: A review comparing the performance of different scoring systems
Jad Mitri, Mohammad Almeqdadi, Raffi Karagozian
Jad Mitri, Department of Medicine, Saint Elizabeth’s Medical Center, Boston, MA 02135, United States
Mohammad Almeqdadi, Division of Transplant and Hepatobiliary Disease, Tufts Medical Center, Boston, MA 02111, United States
Raffi Karagozian, Division of Gastroenterology & Hepatology, Tufts Medical Center, Boston, MA 02111, United States
Author contributions: Mitri J and Almeqdadi M reviewed the literature, planned the outline, and created the tables and figure; Mitri J wrote the manuscript with contributions and supervision from Almeqdadi M and Karagozian R; Almeqdadi M and Karagozian R proofread the manuscript; Almeqdadi M designed figure 1; Mitri J, Almeqdadi M, and Karagozian R revised the manuscript and wrote the comments to reviewers.
Conflict-of-interest statement: The authors declare that there was no conflict of interest regarding the publication of this mini-review.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Raffi Karagozian, MD, Assistant Professor, Division of Gastroenterology & Hepatology, Tufts Medical Center, 800 Washington St, Boston, MA 02111, United States. raffi.karagozian@tuftsmedicine.org
Received: May 4, 2023
Peer-review started: May 4, 2023
First decision: May 27, 2023
Revised: June 24, 2023
Accepted: July 25, 2023
Article in press: July 25, 2023
Published online: August 27, 2023
Core Tip

Core Tip: Clinical prognostic scores for alcohol-associated hepatitis (AAH) are reliable and commonly minimize the need for histological assessment. Model for end stage liver disease (MELD) score is recently showing superiority compared to the commonly used Maddrey Discriminant function for AAH prognostication. Combining MELD at diagnosis with day 4 (or day 7) Lille score when managing severe AAH would be interesting to validate as a superior mean of assessing AAH prognosis. Acute kidney injury is a complication of AAH with significant impact on mortality. It is therefore important to account for when managing AAH.