Retrospective Cohort Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jun 27, 2021; 13(6): 673-685
Published online Jun 27, 2021. doi: 10.4254/wjh.v13.i6.673
Impact of donor-specific antibodies on long-term graft survival with pediatric liver transplantation
Felicitas Leonie Schotters, Jan Beime, Andrea Briem-Richter, Thomas Binder, Uta Herden, Enke Freya Grabhorn
Felicitas Leonie Schotters, Jan Beime, Andrea Briem-Richter, Enke Freya Grabhorn, Department of Pediatric Hepatology and Liver Transplantation, Universitätsklinikum Hamburg-Eppendorf, Hamburg 20246, Germany
Thomas Binder, Department of Transfusion Medicine, Human Leucocyte Antigen Laboratory, University Medicine Rostock, Rostock 18057, Germany
Uta Herden, Department of Hepatobiliary & Transplant Surgery, Universitätsklinikum Hamburg-Eppendorf, Hamburg 20246, Germany
Author contributions: Schotters FL participated in research design, performed the data collection, performed the research and data analysis, created figures and tables and wrote the paper; Beime J performed a critical revision and participated in writing the manuscript; Briem-Richter A participated in research design; Binder T performed a critical revision; Herden U performed a critical revision; Grabhorn E participated in research design, writing the manuscript, performance of the research and supervised the report.
Institutional review board statement: Our study was approved by the responsible ethics committee.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE statement, and the manuscript was prepared and revised according to the STROBE statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Enke Freya Grabhorn, MD, Attending Doctor, Department of Pediatric Hepatology and Liver Transplantation, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, Hamburg 20246, Germany.
Received: January 8, 2021
Peer-review started: January 8, 2021
First decision: March 29, 2021
Revised: April 12, 2021
Accepted: May 21, 2021
Article in press: May 21, 2021
Published online: June 27, 2021
Processing time: 148 Days and 4.6 Hours
Core Tip

Core Tip: This was a retrospective study to evaluate the impact of donor-specific antibodies (DSAs) on graft survival with pediatric liver transplantation. Graft fibrosis and graft loss was significantly higher in patients with DSAs. Screening for DSAs should be included in follow-ups to avoid delayed identification of patients at risk of graft loss (rejection), and may be even more relevant for patients with early histological signs of possible allograft dysfunction (fibrosis). Moreover, patients with DSAs may be poor candidates for reduction of initial immunosuppression or even weaning.