Published online Jul 27, 2022. doi: 10.4254/wjh.v14.i7.1408
Peer-review started: January 21, 2022
First decision: June 7, 2022
Revised: June 20, 2022
Accepted: July 6, 2022
Article in press: July 6, 2022
Published online: July 27, 2022
Further investigations are needed to provide medical and nutritional therapies based on the genetic background of the population and the role of lifestyle changes including diet, exercise and mental health.
Given the differential distribution of gene polymorphisms and rate of dyslipidemias found in this study, primary health care strategies are required to establish preventive actions to mitigate their prevalence considering the regional genetic and cultural differences, which could have important implications for personalized medicine within the new era of precision medicine.
We aimed to describe if there are important differences between Native American and Mestizo Mexicans in regard to the type of dyslipidemias and lipid-related genetic polymorphisms.
In this retrospective study, 1324 adults were selected to compare dyslipidemias and lipid-related gene polymorphisms. Demographic, clinical, and laboratory data were collected. A subgroup of 196 normal weight Mestizo subjects without impaired glucose was selected for the association analyses. Genotyping was determined by allelic discrimination assay.
The Native Americans showed a greater genetic susceptibility for developing hypercholesterolemia (HChol) (APOE4, LDLR) and hypoalphalipoproteinemia (ABCA1). The TT genotype of APOB -516C/T and GG genotype of LDLR A1413G were associated risk factors for HChol and increased low-density lipoprotein cholesterol levels in Mestizo healthy population.
Deciphering the role of ethnicity in the type of dyslipidemia and defining the prevalence of lipid-related gene polymorphisms.
Genetic and environmental factors are involved in the onset and progression of dyslipidemias among the Mexican population.