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World J Hepatol. Nov 27, 2021; 13(11): 1629-1641
Published online Nov 27, 2021. doi: 10.4254/wjh.v13.i11.1629
Current strategies to induce liver remnant hypertrophy before major liver resection
Celeste Del Basso, Martin Gaillard, Panagiotis Lainas, Stella Zervaki, Gabriel Perlemuter, Pierre Chagué, Laurence Rocher, Cosmin Sebastian Voican, Ibrahim Dagher, Hadrien Tranchart
Celeste Del Basso, Martin Gaillard, Panagiotis Lainas, Stella Zervaki, Ibrahim Dagher, Hadrien Tranchart, Department of Minimally Invasive Digestive Surgery, Antoine Béclère Hospital, Clamart 92140, France
Gabriel Perlemuter, Cosmin Sebastian Voican, Department of Hepato-Gastroenterology and Nutrition, Antoine Béclère Hospital, Clamart 92140, France
Pierre Chagué, Laurence Rocher, Department of Radiology, Antoine Béclère Hospital, Clamart 92140, France
Author contributions: Del Basso C, Zervaki S, Voican CS made substantial contributions to conception and design of the study, acquisition of data, analysis and interpretation of data; Del Basso C, Gaillard M, Lainas P and Tranchart H wrote the article and made critical revisions related to important intellectual content of the manuscript; Perlemuter G, Dagher I, Rocher L and Chagué P approved the version of the article to be published.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hadrien Tranchart, MD, PhD, Associate Professor, Department of Minimally Invasive Digestive Surgery, Antoine Béclère Hospital, 157 rue de la Porte de Trivaux, Clamart 92140, France. hadrien.tranchart@aphp.fr
Received: February 23, 2021
Peer-review started: February 23, 2021
First decision: June 4, 2021
Revised: June 8, 2021
Accepted: October 11, 2021
Article in press: October 11, 2021
Published online: November 27, 2021
Abstract

Hepatic resection is the gold standard for patients affected by primary or metastatic liver tumors but is hampered by the risk of post-hepatectomy liver failure. Despite recent improvements, liver surgery still requires excellent clinical judgement in selecting patients for surgery and, above all, efficient pre-operative strategies to provide adequate future liver remnant. The aim of this article is to review the literature on the rational, the preliminary assessment, the advantages as well as the limits of each existing technique for preparing the liver for major hepatectomy.

Keywords: Liver regeneration, Major hepatectomy, Liver insufficiency, Future liver remnant, Portal vein embolization

Core Tip: Hepatic resection is the gold standard for patients affected by liver tumors but is hampered by the risk of post-hepatectomy liver failure. We herein review the literature on the rational, the preliminary assessment, the advantages as well as the limits of each existing technique for preparing the liver for major hepatectomy.