Anirvan P, Bharali P, Gogoi M, Thuluvath PJ, Singh SP, Satapathy SK. Liver injury in COVID-19: The hepatic aspect of the respiratory syndrome — what we know so far. World J Hepatol 2020; 12(12): 1182-1197 [PMID: 33442447 DOI: 10.4254/wjh.v12.i12.1182]
Corresponding Author of This Article
Sanjaya K Satapathy, FAASLD, AGAF, FACG, FASGE, Medical Director Liver Transplantation, Division of Hepatology, Sandra Atlas Bass Center for Liver Diseases and Transplantation, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, 400 Community Drive, Manhasset, NY 11030, United States. ssatapat@northwell.edu
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Hepatol. Dec 27, 2020; 12(12): 1182-1197 Published online Dec 27, 2020. doi: 10.4254/wjh.v12.i12.1182
Liver injury in COVID-19: The hepatic aspect of the respiratory syndrome — what we know so far
Prajna Anirvan, Pankaj Bharali, Mrinal Gogoi, Paul J Thuluvath, Shivaram P Singh, Sanjaya K Satapathy
Prajna Anirvan, Department of Gastroenterology, Sriram Chandra Bhanj Medical College, Cuttack 753007, Odisha, India
Pankaj Bharali, Mrinal Gogoi, Shivaram P Singh, Department of Gastroenterology, Sriram Chandra Bhanj Medical College and Hospital, Cuttack 753007, Odisha, India
Paul J Thuluvath, Department of Surgery and Medicine, Mercy Medical Center, Baltimore, MD 21202, United States
Sanjaya K Satapathy, Division of Hepatology, Sandra Atlas Bass Center for Liver Diseases and Transplantation, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, Manhasset, NY 11030, United States
Author contributions: Singh SP and Satapathy SK contributed to the conception and design of the manuscript; Singh SP, Satapathy SK, Thuluvath PJ, Anirvan P, Bharali P and Gogoi M drafted the initial manuscript; All authors participated in the critical revision of the manuscript for important intellectual contents and approved the final manuscript.
Supported byKalinga Gastroenterology Foundation, Cuttack, India.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Sanjaya K Satapathy, FAASLD, AGAF, FACG, FASGE, Medical Director Liver Transplantation, Division of Hepatology, Sandra Atlas Bass Center for Liver Diseases and Transplantation, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health, 400 Community Drive, Manhasset, NY 11030, United States. ssatapat@northwell.edu
Received: September 6, 2020 Peer-review started: September 6, 2020 First decision: October 5, 2020 Revised: October 21, 2020 Accepted: November 17, 2020 Article in press: November 17, 2020 Published online: December 27, 2020
Abstract
The 2019 novel coronavirus disease (COVID-19) pandemic due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a serious threat to global public health. Although primarily, the infection causes lung injury, liver enzyme abnormalities have also been reported to occur during the course of the disease. We conducted an extensive literature review using the PubMed database on articles covering a broad range of issues related to COVID-19 and hepatic injury. The present review summarizes available information on the spectrum of liver involvement, the possible mechanisms and risk factors of liver injury due to SARS-CoV-2 infection, and the prognostic significance of the presence of liver injury. Hopefully, this review will enable clinicians, especially the hepatologists, to understand and manage the liver derangements they may encounter in these patients better and provide guidance for further studies on the liver injury of COVID-19.
Core Tip: Hepatic injury in coronavirus disease 2019 (COVID-19) has been widely observed. Although the pathogenic mechanisms still remain unclear, it is believed to be due to interplay of multiple factors. In this review, we have tried to discuss the pathophysiological mechanisms of hepatic injury in the context of COVID-19 and have proposed a management outline of such injury.
