Published online Mar 27, 2019. doi: 10.4254/wjh.v11.i3.330
Peer-review started: January 14, 2019
First decision: February 22, 2019
Revised: February 27, 2019
Accepted: March 16, 2019
Article in press: March 16, 2019
Published online: March 27, 2019
Serum levels of cartilage oligomeric matrix protein (COMP) has been presented as a biomarker of liver fibrosis in several cross-sectional studies. COMP is also an essential mediator in carcinoma development and has also been associated with hepatocellular carcinoma. We present a prospective analysis of this biomarker in 38 patients with chronic hepatitis C who were subject to eradication therapy with direct acting antivirals. We confirm previous studies associating COMP elevation with liver cirrhosis. We also show how viral levels are correlated with COMP at baseline. In our prospective analysis, we report that successful eradication of hepatitis C results in improvement in liver stiffness and laboratory liver function tests at 1 year follow-up. In contrast, median COMP-levels remain unchanged during the study period. We conclude that the biomarker potential of COMP in the prospective evaluation of liver diseases, remains to be elucidated.
Core tip: Cartilage oligomeric matrix protein (COMP) is a biomarker of fibrosis that has recently been introduced in the field of hepatology. COMP has also been associated with tumor development. This is the first prospective study of COMP in chronic liver disease. We confirm previous findings, relating S-COMP to liver cirrhosis. Eradication of hepatitis C was associated with improvements of liver function test and liver elasticity. In contrast, and unexpectedly, S-COMP remained unchanged in this cohort. We argue that the biomarker potential of COMP in chronic liver diseases needs further exploration, especially in reference to carcinoma development.