Published online Feb 27, 2018. doi: 10.4254/wjh.v10.i2.297
Peer-review started: November 25, 2017
First decision: December 18, 2017
Revised: January 13, 2018
Accepted: January 23, 2018
Article in press: January 24, 2018
Published online: February 27, 2018
To examine the association between weekend alcohol consumption and the biochemical and histological alterations at two different concentrations of alcohol in both genders in rats.
Wistar rats weighing 170-200 g were divided into groups as follows: (1) Control groups; and (2) weekend alcohol-consumption group: 2 d/weekly per 12 wk, at two different concentrations: (1) Group of males or females with a consumption of a solution of alcohol at 40%; and (2) group of males or females with a consumption of a solution of alcohol at 5%. At the end of the experiment, serum and liver samples were obtained. The following enzymes and metabolites were determined in serum: Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Lactate Dehydrogenase, and Gamma-Glutamyltransferase, and glucose, triglycerides, cholesterol, bilirubin, and albumin. Liver samples from each group were employed to analyze morphological abnormalities by light microscopy.
In all of the weekend alcohol-consumption groups, AST activity presented a significant, 10-fold rise. Regarding ALT activity, the groups with weekend alcohol consumption presented a significant increase that was six times greater. Bilirubin levels increased significantly in both groups of females. We observed a significant increase in the parameters of fatty change and inflammation due to weekend alcohol consumption. Only the group of females that consumed alcohol at 40% presented slight hepatocellular disorganization
The results obtained herein provide solid evidence that weekend alcohol consumption gives rise to liver damage, demonstrated by biochemical and histological alterations, first manifested acutely, and prolonged weekend alcohol consumption can cause greater, irreversible damage.
Core tip: At present, it is considered that the main weekend alcohol consumers comprises the young population, due to the gratifying effect of alcohol, this being a very important social and health problem. Our findings demonstrate an effect of the damage that is caused by weekend alcohol consumption, regardless of gender or the concentration of alcohol. Even more so, greater damage can be observed in females, and the metabolism of ethanol probably participates, specifically due to its first-pass metabolism, which is carried out in the stomach.