Long non-coding RNA SNHG16 promotes human placenta-derived mesenchymal stem cell proliferation capacity through the PI3K/AKT pathway under hypoxia

Table 1 Summary of the RNA sequencing data

Summary	MSC_N1	MSC_N2	MSC_N3	MSC_H1	MSC_H2	MSC_H3
Raw reads (M)	103.22	113.01	117.09	114.00	117.77	106.81
Clean reads (M)	99.95	109.86	113.73	110.04	113.72	103.86
Clean reads rate (%)	96.83	97.21	97.13	96.53	96.56	97.24
Q30 (%)	94.32	94.63	94.62	94.22	94.18	94.78
GC (%)	46.71	45.65	45.35	46.18	44.99	45.92
Total mapped reads	320502139			324502629
Uniquely mapped reads	308534583			312982527

Q30 (%) represents the proportion of the data in which the quality values are > Q30 in the raw data; MSC_N: Human placenta-derived mesenchymal stem cells cultured under normoxic condition; MSC_H: Human placenta-derived mesenchymal stem cells cultured under hypoxic condition.

Table 2 Summary of the top 20 differentially expressed long non-coding RNAs

Upregulated lncRNA	Fold-change	Downregulated lncRNA	Fold-change
ENST00000480904	144.7046633	TCONS_00024987	558.6529515
ENST00000420168	88.58973499	TCONS_00022901	305.9141231
ENST00000447687	51.87793204	ENST00000580684	101.5147448
TCONS_00022897	43.87602707	XR_951092.3	96.15131381
NR_135828.1	43.01226344	TCONS_00040744	85.07807992
ENST00000652331	37.64067361	NR_151707.1	75.91477831
ENST00000615566	35.57471309	XR_924538.2	51.52143558
XR_001740831.1	30.29369126	ENST00000533146	47.14143364
XR_943245.2	29.4766044	NR_046472.1	45.2199291
ENST00000641463	29.12107436	ENST00000379848	34.42041339
ENST00000587838	28.77216197	XR_002957073.1	33.6627267
NR_027295.2	28.51478291	NR_138037.1	31.71645024
XR_001738493.2	26.08189868	ENST00000424751	31.28206241
ENST00000622955	24.98325918	ENST00000476224	29.12601955
ENST00000437589	23.11958922	NR_152515.1	28.62941025
NR_028397.1	22.10295425	ENST00000608741	25.94241325
NR_138259.1	21.16258012	XR_001740695.2	25.76946681
XR_947992.2	21.13351381	NR_102280.1	25.69150571
XR_930796.2	18.16731229	ENST00000513626	23.42886779
ENST00000542086	17.05330496	NR_132369.1	21.10943719

lncRNA: Long non-coding RNA.

Table 3 Summary of the top 20 differentially expressed messenger RNAs

Upregulated mRNA	Fold-change	Downregulated mRNA	Fold-change
S100A1	32.28708068	MMP13	32.7146796
IL20	31.01976446	RASAL3	25.22521191
GUCY2D	18.95647724	ITGAM	21.2376519
PIK3R5	16.27652505	FGF14	13.88641698
KCNJ15	9.485618545	KCNS2	9.402226087
CA9	9.092268285	DCT	7.332486828
AK4	8.577190243	TMEM247	6.224926429
CD99	7.853653254	TNFRSF4	5.89336975
VSIG2	6.545400641	SOX7	5.002461264
CKMT2	6.072884506	TXNIP	3.914446648
FOLR1	5.195878685	NBPF6	3.514713231
C5orf46	5.180793591	PDF	3.476083157
PPFIA4	4.979164209	LHX4	3.46662373
TEC	4.732591252	CD14	3.005111835
INHBB	4.597149928	HHIPL2	2.918560997
GLDC	4.140246682	RASL11B	2.770760137
GPR146	4.107008037	LMO3	2.767289903
VASH2	4.051761622	MYH11	2.728808288
C4orf47	3.969880654	DIRAS2	2.718905726
SCHIP1	3.945719906	AJM1	2.696612138

mRNA: Messenger RNA.