Copyright ©The Author(s) 2020.
World J Stem Cells. Sep 26, 2020; 12(9): 897-921
Published online Sep 26, 2020. doi: 10.4252/wjsc.v12.i9.897
Table 2 A vast number of these investigations indicate the importance of various scaffolds to design effective tissue engineering approaches
ScaffoldGrowth factors/bioactive moleculesExperimental modelTarget tissueRef.
Silicon-In vitroTeeth[168]
Collagen spongeSCFIn vitro and in vivo (mice)Teeth[126]
Collagen type I and type IIISDF-1In vivo (dogs)Teeth[91]
Collagen type-I and N-acetic acidSDF-1, bFGF, BMP-7In vitro and in vivo (rats)Teeth[120]
Collagen/chitsosan-In vitro-[129]
Collagen-polyvinylpyrrolidone sponge-Case reportTeeth[144]
Silk fibroinSDF-1In vitro and in vivo (mice)Teeth[123]
Acellular dental pulp ECM-In vivo (mice)Teeth[108]
Intrafibrillar-silicified collagen-In vitro and in vivo (mice)Teeth[169]
MatrigelbFGF-2, TGF-β1In vitro-[121]
Peptide hydrogelVEGF, TGF-β1, FGF-1In vivo (mice)Teeth[118]
Gelatin methacrylate hydrogel-In vivo (rats)Teeth[133]
PuraMatrix™VEGFIn vivo (mice)Teeth[134]
Poly-ε-caprolactone and hydroxyapatiteSDF-1, BMP-7In vitro and in vivo (rats)Teeth[124]
Polycaprolactone-poly-glycolic acidBMP-7In vitro and in vivo (mice)Teeth[97]
Thermoresponsive hydrogel-In vitro and in vivo (mice)Teeth[111]
DL-lactide/co-polymer of L-lactide /DL-lactide, and hydroxyapatite tricalcium phosphateBMP-2In vitro and in vivo (mice)Teeth[132]
3D hydroxyapatite scaffolds containing peptide hydrogels-In vivo (mice)Teeth[112]
Poly-lactic-co-glycolic acid-In vitro and in vivo (mice)Teeth[104]
Beta-tricalcium phosphate scaffoldBMP-2In vitro and in vivo (mice)Teeth[131]
Collagen sponge-Clinical trialBone[153]
Collagen sponge-Clinical trialBone[151]
Collagen sponge-Clinical trialBone[152]
Chitosan/gelatinBMP-2In vitro and in vivo (mice)Bone[92]
Arginine-glycine-aspartic acid-In vitro and in vivo (mice)Bone[141]
Granular 3D chitosan-In vitroNeural tissue[193]
MatrigelBMP-9In vitro and in vivo (mice)Bone[180]
3D nano-fibrous gelatin/silica bioactive glass hybrid-In vitroTeeth[107]
3D gel collagen matrixBMP-2In vitro and in vivo (rats)Bone[177]
Poly-ε-caprolactone biphasic calcium phosphate-In vitro and in vivo (rabbit)Bone[160]
Glass nanoparticles/chitosan-gelatin-In vitro and in vivo (rats)Bone[159]
3D poly-lactideExtracellular vesiclesIn vitro and in vivo (rats)Bone[179]
2D monolayer culture/3D poly lactic-co-glycolic-In vitroBone[174]
Dense collagen gel or acellular-In vivo (rats)Bone[150]
Calcium phosphate cement functionalized with iron oxide nanoparticles-In vitroBone[166]
Poly-lactic-co-glycolic acid-In vitro and in vivo (rats)Bone[164]
Hydroxyapatite-collagen sponge-Clinical trialBone[146]
3D porous chitosanbFGFIn vitroNeural tissue[201]
Fibrin and collagen-In vivo (rats)Sciatic nerves[9]
CollagenTetracyclineIn vivo (mice)Sciatic nerves[206]
Collagen-In vitro and in vivo (rats)Sciatic nerves[210]
3D alginate/hyaluronic acidNGFIn vitro and in vivo (mice)Peripheral nerves[207]
Collagen sponge (DSCs condition medium)-In vitro and in vivo (rats)Facial nerves[211]
3D bio-printing of scaffold-free nervous tissue-In vitro and in vivo (rats)Facial nerves[208]
Chitosan-In vitro and in vivo (rats)Spinal cord[198]
Aligned electrospun poly-ε-caprolactone/ poly-lactide-co-glycolic acid-In vitro and in vivo (rats)Spinal cord[202]