de Almeida DC, Evangelista LSM, Câmara NOS. Role of aryl hydrocarbon receptor in mesenchymal stromal cell activation: A minireview. World J Stem Cells 2017; 9(9): 152-158 [PMID: 29026461 DOI: 10.4252/wjsc.v9.i9.152]
Corresponding Author of This Article
Danilo Candido de Almeida, PhD, Affiliate Professor, Department of Medicine, Nephrology Division, Federal University of São Paulo, Rua Pedro de Toledo, 669 - 10 Andar - Frente, Vila Clementino, São Paulo, SP 04039-003, Brazil. d.almeida@unifesp.br
Research Domain of This Article
Cell Biology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Sep 26, 2017; 9(9): 152-158 Published online Sep 26, 2017. doi: 10.4252/wjsc.v9.i9.152
Role of aryl hydrocarbon receptor in mesenchymal stromal cell activation: A minireview
Danilo Candido de Almeida, Laura Sibele Martins Evangelista, Niels Olsen Saraiva Câmara
Danilo Candido de Almeida, Laura Sibele Martins Evangelista, Niels Olsen Saraiva Câmara, Department of Medicine, Nephrology Division, Federal University of São Paulo, São Paulo, SP 04039-003, Brazil
Niels Olsen Saraiva Câmara, Department of Immunology, Institute of Biomedical Science, University of São Paulo, São Paulo, SP 05508-000, Brazil
Author contributions: de Almeida DC and Evangelista LSM wrote the manuscript; Câmara NOS contributed to extensive review and supervision.
Supported by São Paulo Research Public Foundation FAPESP and National Counsel of Technological and Scientific Development CNPq, No. 07/07193-3 and No. 12/02270-2.
Conflict-of-interest statement: The authors declare no potential conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Danilo Candido de Almeida, PhD, Affiliate Professor, Department of Medicine, Nephrology Division, Federal University of São Paulo, Rua Pedro de Toledo, 669 - 10 Andar - Frente, Vila Clementino, São Paulo, SP 04039-003, Brazil. d.almeida@unifesp.br
Telephone: +55-11-55764841
Received: March 29, 2017 Peer-review started: March 31, 2017 First decision: April 18, 2017 Revised: June 21, 2017 Accepted: July 7, 2017 Article in press: July 9, 2017 Published online: September 26, 2017
Core Tip
Core tip: The aryl-hydrocarbon receptor (AhR) is an endogenous sensor expressed in mesenchymal stromal cells (MSCs), regulating their immunomodulatory function. Therefore, in this review, we summarize important reports that demonstrate that AhR activation can substantially modulate the function of MSCs by mechanisms associated with: (1) The induction of the death signal in pro-inflammatory cells; (2) the suppression of pro-inflammatory genes/cytokines; (3) the improvement of migration and regenerative potential in acute inflammatory models; (4) the inhibition of mesodermal differentiation; and (5) the up-regulation of global immunosuppression. Thus, the influence of AhR activation on MSC function can establish new perspectives on MSC-based therapies, especially for immune-associated diseases.
