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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Apr 26, 2015; 7(3): 657-668
Published online Apr 26, 2015. doi: 10.4252/wjsc.v7.i3.657
Published online Apr 26, 2015. doi: 10.4252/wjsc.v7.i3.657
Smart scaffolds in bone tissue engineering: A systematic review of literature
Saeed Reza Motamedian, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran PO Box 19839, Iran
Sepanta Hosseinpour, Mitra Ghazizadeh Ahsaie, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran PO Box 19839, Iran
Arash Khojasteh, Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran PO Box 19839, Iran
Author contributions: All authors contributed to this manuscript.
Conflict-of-interest: The authors declare no conflict of interest.
Data sharing: This study was a literature review and no additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Arash Khojasteh, DMD, MS, Department of Oral and Maxillofacial Surgery, School of Dentistry, Shahid Beheshti University of Medical Sciences, Daneshjou Boulevard, Evin, Tehran PO Box 19839, Iran. arashkhojasteh@yahoo.com
Telephone: +98-912-1060032 Fax: +98-21-88507688
Received: July 29, 2014
Peer-review started: July 29, 2014
First decision: September 28, 2014
Revised: December 10, 2014
Accepted: December 29, 2014
Article in press: December 31, 2014
Published online: April 26, 2015
Peer-review started: July 29, 2014
First decision: September 28, 2014
Revised: December 10, 2014
Accepted: December 29, 2014
Article in press: December 31, 2014
Published online: April 26, 2015
Core Tip
Core tip: Currently, special attention has been directed to the design of new scaffolds by adding bioactive molecules and nanoparticles. “Smart scaffolds” in bone tissue engineering not only act as cell delivery materials, but they are also responsive to their environment and therefore stem cells are more likely to attach, proliferate and differentiate on them. These scaffolds can be fabricated by adding either of growth factors, extracellular matrix proteins or nanoparticles to the bone substitutes using various techniques. These modifications can enhance the in vitro response of bone scaffolds toward cells.