Published online Nov 26, 2015. doi: 10.4252/wjsc.v7.i10.1215
Peer-review started: June 10, 2015
First decision: August 4, 2015
Revised: September 30, 2015
Accepted: October 23, 2015
Article in press: October 27, 2015
Published online: November 26, 2015
Core tip: Recently, the plasticity of postnatal stem cells from dental origin including human dental pulp stem cells (hDPSCs) has been suggested. Their osteogenic potential makes them valuable for craniofacial bone regeneration. hDPSCs can be easily isolated from dental medical wastes, extracted teeth, and expanded ex vivo. Combination of numerous postnatal stem cells and three-dimensional scaffold biomaterials has been used in bone tissue engineering. Selection of an ideal scaffold biomaterial is a challenging part of reconstructive surgeries. Current study aims to evaluate behavior of hDPSCs including adhesion, proliferation, morphology and differentiation on four different scaffold biomaterials. Our finding indicates that PLLA (Synthetic) scaffold supports adhesion, proliferation and osteogenic differentiation of hDPSCs. Therefore, it can be useful for the purpose of craniofacial tissue engineering.