Published online Jul 26, 2013. doi: 10.4252/wjsc.v5.i3.73
Revised: April 18, 2013
Accepted: June 5, 2013
Published online: July 26, 2013
Core tip: Here, we provided a summary on epigenetics and chromatin structure in pluripotent embryonic stem cells (ESCs) and their differentiated counterpart. We especially aim at histone signature, function of heterochromatin protein 1. Moreover, we summarized published data on nuclear architecture; we especially addressed arrangement of chromosome territories and genes in pluripotent ESCs and after induced differentiation.