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World J Stem Cells. Jul 26, 2013; 5(3): 73-85
Published online Jul 26, 2013. doi: 10.4252/wjsc.v5.i3.73
Epigenetics and chromatin plasticity in embryonic stem cells
Terézia Přikrylová, Jiří Pacherník, Stanislav Kozubek, Eva Bártová
Terézia Přikrylová, Stanislav Kozubek, Eva Bártová, Institute of Biophysics, Academy of Sciences of the Czech Republic, 612 65 Brno, Czech Republic
Jiří Pacherník, Department of Animal Physiology, Faculty of Sciences, Masaryk University, 602 00 Brno, Czech Republic
Author contributions: Přikrylová T substantially contributed to the concept of the review; Pacherník J and Kozubek S improved the content of the article; Bártová E finalized the text, made final design of images and performed image acquisition.
Supported by Grants P302/12/G157 and 13-07822S from the Grant Agency of the Czech Republic and by COST-CZ project LD11020 of the Ministry of Education Youth and Sport of the Czech Republic; Bártová E is a coordinator of the EU Marie Curie Project PIRSES-GA-2010-269156-LCS.
Correspondence to: Eva Bártová, Associate Professor, Institute of Biophysics, Academy of Sciences of the Czech Republic, v.v.i., Královopolská 135, 612 65 Brno, Czech Republic.
Telephone: +420-5-41517141 Fax: +420-5-41240498
Received: February 4, 2013
Revised: April 18, 2013
Accepted: June 5, 2013
Published online: July 26, 2013
Core Tip

Core tip: Here, we provided a summary on epigenetics and chromatin structure in pluripotent embryonic stem cells (ESCs) and their differentiated counterpart. We especially aim at histone signature, function of heterochromatin protein 1. Moreover, we summarized published data on nuclear architecture; we especially addressed arrangement of chromosome territories and genes in pluripotent ESCs and after induced differentiation.