Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Stem Cells. Sep 26, 2026; 18(9): 124169
Published online Sep 26, 2026. doi: 10.4252/wjsc.124169
Published online Sep 26, 2026. doi: 10.4252/wjsc.124169
Induced pluripotent stem cell-derived neuronal models in psychiatry: Mechanistic insights and translational horizons
Moria Maman, Research and Development, NeuroKaire, Tel Aviv-Yafo 6744332, Tel Aviv, Israel
Orit Goldman, Talia Cohen Solal, Daphna Laifenfeld, NeuroKaire, Tel Aviv-Yafo 6744332, Tel Aviv, Israel
Author contributions: Maman M conceived the review, performed the literature search, analyzed and interpreted the literature, prepared the figure and table, and wrote the original manuscript; Goldman O, Cohen Solal T, and Laifenfeld D critically revised the manuscript for important intellectual content and contributed to the interpretation of the literature. All authors reviewed, approved the final version of the manuscript, and agree to be accountable for all aspects of the work.
AI contribution statement: Portions of this manuscript were edited using AI tools solely for language refinement. The authors carefully reviewed and verified all AI-assisted outputs and take full responsibility for the scientific content of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Moria Maman, PhD, Research and Development, NeuroKaire, Yigal Alon 126, Tel Aviv-Yafo 6744332, Tel Aviv, Israel. moria@neurokaire.com
Received: June 9, 2026
Revised: July 13, 2026
Accepted: August 26, 2026
Published online: September 26, 2026
Processing time: 108 Days and 13.9 Hours
Revised: July 13, 2026
Accepted: August 26, 2026
Published online: September 26, 2026
Processing time: 108 Days and 13.9 Hours
Core Tip
Core Tip: Human induced pluripotent stem cell-derived neuronal models are transforming psychiatric research by enabling direct investigation of patient-specific neural phenotypes in a human genetic context. Beyond disease modeling, emerging evidence suggests that quantitative functional phenotyping can identify biologically meaningful patient subgroups and treatment-response signatures. This review synthesizes findings across major psychiatric disorders and proposes a conceptual shift from reproducing diagnostic categories in vitro toward mechanism-based stratification. Such approaches may bridge the gap between psychiatric genetics and clinical decision-making, advancing the development of precision psychiatry.