Author contributions: Wang JJ and Xu HJ contributed to the manuscript writing; Xu HJ contributed to conceptualization and revision; Wang JJ contributed to language editing and financial support. All authors have read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Hong-Jie Xu, PhD, Associate Professor, The Fifth Affiliated Hospital, Guangzhou Medical University, No. 188 Kaiyuan Avenue, Huangpu District, Guangzhou 510535, Guangdong Province, China. xuhongjie316@163.com
Received: July 4, 2025 Revised: July 21, 2025 Accepted: September 3, 2025 Published online: September 26, 2025 Processing time: 82 Days and 20.7 Hours
Core Tip
Core Tip: This commentary examines the study by Wang et al on the role of human umbilical cord mesenchymal stromal cell-derived exosomes in alleviating radiation induced pulmonary fibrosis. However, some issues are worth discussing. First, regarding the definitions of mesenchymal stromal cells and exosomes, according to the latest standards, mesenchymal stromal cell should represent mesenchymal stromal cell, and the so-called exosomes should be extracellular vesicles. Secondly, there are some imprecise or incorrect parts in the text that need to be clarified, especially the evidence for the AKT signaling pathway may be insufficient. Thirdly, this article more systematically discusses the current progress of extracellular vesicles in the treatment of pulmonary fibrosis.
