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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Aug 26, 2022; 14(8): 577-586
Published online Aug 26, 2022. doi: 10.4252/wjsc.v14.i8.577
Published online Aug 26, 2022. doi: 10.4252/wjsc.v14.i8.577
Pancreatic transplant surgery and stem cell therapy: Finding the balance between therapeutic advances and ethical principles
Martina Padovano, Federico Manetti, Donato Morena, Nicola Di Fazio, Paola Frati, Vittorio Fineschi, Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Rome 00185, Italy
Matteo Scopetti, Department of Medical Surgical Sciences and Translational Medicine, Sapienza University of Rome, Rome 00189, Italy
Davide Radaelli, Stefano D’Errico, Department of Medicine, Surgery and Health, University of Trieste, Trieste 34149, Italy.
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting, critical revision, and approval of the final version.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Vittorio Fineschi, MD, PhD, Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Sapienza University of Rome, Viale Regina Elena 336, Rome 00185, Italy. vittorio.fineschi@uniroma1.it
Received: March 18, 2022
Peer-review started: March 18, 2022
First decision: May 11, 2022
Revised: May 24, 2022
Accepted: August 1, 2022
Article in press: August 1, 2022
Published online: August 26, 2022
Peer-review started: March 18, 2022
First decision: May 11, 2022
Revised: May 24, 2022
Accepted: August 1, 2022
Article in press: August 1, 2022
Published online: August 26, 2022
Core Tip
Core Tip: Recent research in pancreatic transplantation is involving many branches of medicine. The objective is represented by the achievement of euglycemia and the anatomo-functional restoration of the β-cells, avoiding exogenous insulin administration. Transplantation of the pancreas or pancreatic islets (eventually associated with renal transplantation) and stem cell therapy constitute the new frontiers in this field. However, such rapid scientific growth must be followed by an extensive discussion on the ethical implications to make experimental and clinical practices adequate and sustainable.