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World J Stem Cells. Jul 26, 2020; 12(7): 604-611
Published online Jul 26, 2020. doi: 10.4252/wjsc.v12.i7.604
Vitamin D and calcium signaling in epidermal stem cells and their regeneration
Yuko Oda, Daniel D Bikle
Yuko Oda, Daniel D Bikle, Department of Medicine, University of California San Francisco, CA 94158, United States
Yuko Oda, Daniel D Bikle, Endocrine Research, Veterans Affairs Medical Center San Francisco, CA 94158, United States
Author contributions: Oda Y overviewed related studies, prepared a model and wrote the review paper; Bikle DD reviewed and edited the paper.
Supported by the National Institute of Health (NIH) grant, No. R21 DE025357 (to Oda Y), and No. R01 AR050023 (to Bikle DD); DOD grant, No. CA110338 (to Bikle DD); and VA Merit, No. I01 BX003814-01 (to Bikle DD).
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Yuko Oda, PhD, Associate Research Scientist, Endocrine Research 111N-MB 630, Veterans Affairs Medical Center San Francisco, University of California San Francisco, 1700 Owens Street, San Francisco, CA 94158, United States. yuko.oda@ucsf.edu
Received: February 25, 2020
Peer-review started: February 25, 2020
First decision: April 22, 2020
Revised: May 18, 2020
Accepted: June 10, 2020
Article in press: June 10, 2020
Published online: July 26, 2020
Core Tip

Core tip: Vitamin D and calcium signaling play critical roles in epidermal stem cells and progeny to regenerate the epidermis during cutaneous wound healing. Their regulation of these processes is mediated at least in part through β-catenin and E-cadherin mediated adherens junction signaling.