Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jun 26, 2020; 12(6): 422-437
Published online Jun 26, 2020. doi: 10.4252/wjsc.v12.i6.422
Stem cell-based approaches: Possible route to hearing restoration?
María Beatriz Durán-Alonso
María Beatriz Durán-Alonso, Institute of Biology and Molecular Genetics, University of Valladolid, Valladolid 47003, Spain
Author contributions: Durán-Alonso MB revised the published data and wrote the paper.
Conflict-of-interest statement: The author declares no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: María Beatriz Durán-Alonso, PhD, Postdoctoral Fellow, Postdoctoral scientist, Institute of Biology and Molecular Genetics, University of Valladolid, C/ Sanz y Forés 3, Valladolid 47003, Spain.
Received: February 29, 2020
Peer-review started: February 29, 2020
First decision: April 25, 2020
Revised: May 8, 2020
Accepted: May 21, 2020
Article in press: May 21, 2020
Published online: June 26, 2020
Core Tip

Core tip: This review summarizes the various approaches that are being explored to establish cell-based therapies that tackle the irreversible loss of sensory cells in the adult cochlea. Advantages and disadvantages of the various approaches are discussed, based on published results, and some considerations are made on future perspectives, taking into account the new developments in the field.