Published online Jun 26, 2020. doi: 10.4252/wjsc.v12.i6.406
Peer-review started: January 16, 2020
First decision: April 7, 2020
Revised: April 29, 2020
Accepted: May 27, 2020
Article in press: May 27, 2020
Published online: June 26, 2020
Core tip: The role of cancer stem cells (CSCs) in tumour aggressiveness, progression, recurrence and resistance to cancer therapy is well appreciated. However, therapeutic strategies to target CSCs for cancer therapy has still not progressed sufficiently, particularly in terms of exploring the mechanism of dynamic interconversion between CSCs and non-CSCs. Similar to other cells, CSCs also release exosomes loaded with microRNAs (miRs) as part of their paracrine activity. Our review focusses on the exosomal payload of miRs released by cancer cells and their role in the diagnosis as well as prognosis of lung cancer patients.