Basic Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Apr 26, 2020; 12(4): 277-287
Published online Apr 26, 2020. doi: 10.4252/wjsc.v12.i4.277
Ability of human umbilical cord mesenchymal stem cells to repair chemotherapy-induced premature ovarian failure
Jian Shen, Dai Cao, Jing-Li Sun
Jian Shen, Dai Cao, Jing-Li Sun, Department of Obstetrics and Gynecology, General Hospital of Northern Theater Command (Heping Campus), Shenyang 110000, Liaoning Province, China
Author contributions: All authors helped to perform the research; Shen J made the manuscript writing, performing procedures, data analysis and interpretation; Sun JL designed research; Cao D collected material and clinical data from patients.
Institutional animal care and use committee statement: The study was reviewed and approved by the Institutional Animal Care and Use Committee at General Hospital of Northern Theater Command.
Conflict-of-interest statement: No conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Jing-Li Sun, MAMS, Chief Physician, Department of Obstetrics and Gynecology, General Hospital of Northern Theater Command (Heping Campus), No. 5 Guangrong Street, Heping District, Shenyang 110000, Liaoning Province, China.
Received: December 1, 2019
Peer-review started: December 1, 2019
First decision: January 13, 2020
Revised: March 19, 2020
Accepted: March 26, 2020
Article in press: March 26, 2020
Published online: April 26, 2020
Core Tip

Core tip: Human umbilical cord mesenchymal stem cells (hUCMSCs) can repair ovarian tissue damaged by chemotherapy to a certain extent, can improve the degree of apoptosis in ovarian tissue, and can improve the endocrine function of mouse ovaries. The effect of hUCMSCs on chemotherapy-induced premature ovarian failure mice was observed by closely monitoring the changes in mouse ovarian structure and endocrine function to further verify whether hUCMSCs can be used in the treatment of chemotherapy-induced premature ovarian failure.