Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Mar 26, 2019; 11(3): 167-179
Published online Mar 26, 2019. doi: 10.4252/wjsc.v11.i3.167
Long non-coding RNA: The functional regulator of mesenchymal stem cells
Zhong-Yu Xie, Peng Wang, Yan-Feng Wu, Hui-Yong Shen
Zhong-Yu Xie, Peng Wang, Hui-Yong Shen, Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, Guangdong Province, China
Yan-Feng Wu, Center for Biotherapy, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, Guangdong Province, China
Author contributions: Xie ZY and Wang P conceived the manuscript and collected supportive literature; Wu YF and Shen HY revised and proofread the manuscript.
Supported by the National Natural Science Foundation of China, Nos. 81672097, 81672128, and 81702120.
Conflict-of-interest statement: The authors have no potential conflicts of interests to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Hui-Yong Shen, MD, PhD, Professor, Department of Orthopedics, The Eighth Affiliated Hospital, Sun Yat-sen University, No. 3025, Shennan Middle Road, Futian District, Shenzhen 518033, Guangdong Province, China.
Telephone: +86-20-81332612 Fax: +86-20-81332319
Received: January 13, 2019
Peer-review started: January 14, 2019
First decision: January 26, 2019
Revised: February 7, 2019
Accepted: February 27, 2019
Article in press: February 28, 2019
Published online: March 26, 2019
Core Tip

Core tip: Mesenchymal stem cells (MSCs) are an important kind of multipotent stroma cells in vivo. The various and powerful functions of MSCs are under the control of long non-coding RNA (LncRNA). Previously, many studies have been conducted to illustrate the role of LncRNA in the functions of MSCs. In this review, we highlight LncRNA as a great functional regulator of MSCs and discuss their participation in the pathogenesis of diseases and clinical use in diagnosis and treatment.