Published online Mar 26, 2019. doi: 10.4252/wjsc.v11.i3.167
Peer-review started: January 14, 2019
First decision: January 26, 2019
Revised: February 7, 2019
Accepted: February 27, 2019
Article in press: February 28, 2019
Published online: March 26, 2019
Mesenchymal stem cells (MSCs) are a subset of multipotent stroma cells residing in various tissues of the body. Apart from supporting the hematopoietic stem cell niche, MSCs possess strong immunoregulatory ability and multiple differentiation potentials. These powerful capacities allow the extensive application of MSCs in clinical practice as an effective treatment for diseases. Therefore, illuminating the functional mechanism of MSCs will help to improve their curative effect and promote their clinical use. Long noncoding RNA (LncRNA) is a novel class of noncoding RNA longer than 200 nt. Recently, multiple studies have demonstrated that LncRNA is widely involved in growth and development through controlling the fate of cells, including MSCs. In this review, we highlight the role of LncRNA in regulating the functions of MSCs and discuss their participation in the pathogenesis of diseases and clinical use in diagnosis and treatment.
Core tip: Mesenchymal stem cells (MSCs) are an important kind of multipotent stroma cells in vivo. The various and powerful functions of MSCs are under the control of long non-coding RNA (LncRNA). Previously, many studies have been conducted to illustrate the role of LncRNA in the functions of MSCs. In this review, we highlight LncRNA as a great functional regulator of MSCs and discuss their participation in the pathogenesis of diseases and clinical use in diagnosis and treatment.